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Medical Forum / Diseases and Disorders / AIDS / January 2006AIDS solved - Syphilis living in white blood cells resists treatment
breakthrough from Lyme desease science with Dr. Marshall. Borrelia and Treponema are building longtime cysts: http://autoimmunityresearch.org/trevor-30th.ram Th1 immune response breaks down. (Th2 immune response with more and more actin, p24, reverse transcriptase and other antibodies becomes only weapon of defense. this only for our HIV-fans) see http://www.colman.net video about syphilis > breakthrough from Lyme desease science with Dr. Marshall. > Borrelia and Treponema are building longtime cysts: [quoted text clipped - 9 lines] > > see http://www.colman.net video about syphilis Great info. Wasn't there someone a while ago who tried to explain AIDS through syphilis? Alex > > breakthrough from Lyme desease science with Dr. Marshall. > > Borrelia and Treponema are building longtime cysts: [quoted text clipped - 12 lines] > Great info. Wasn't there someone a while ago who > tried to explain AIDS through syphilis? dont know who it was. have you seen the video from Dr. Marshall? > > breakthrough from Lyme desease science with Dr. Marshall. > > Borrelia and Treponema are building longtime cysts: [quoted text clipped - 13 lines] > > Alex TODAY in our spirochete series: longtime survivor are more and more people with NO history of STDs. here a typical story of a 20-year p24-patient: http://healsd.topcities.com/joyce.htm snip >TODAY in our spirochete series: > >longtime survivor are more and more people with NO history of STDs. >here a typical story of a 20-year p24-patient: > >http://healsd.topcities.com/joyce.htm Has nothing to do with spirochetes. Some people with HIV do not appear to see CD4 declines and remain healthy. The clinical presentation associated with syphilis is quite distinct from HIV. They are not the same. Syphilis is not even a necessary cofactor for AIDS to develop. Tertiary syphilis can take DECADES to manifest. AIDS generally develops on average around 8 years after infection. George M. Carter >Has nothing to do with spirochetes. a past infection with spirochetes has to do with STDs. the doctors told Joyce her HIV-p24 is her lucky gene. isnt that silly? >>Has nothing to do with spirochetes. > >a past infection with spirochetes has to do with STDs. All spirochetes?? They're all the same?? Lyme disease is an STD??? >the doctors told Joyce her HIV-p24 is her lucky gene. >isnt that silly? Yes. What doctors? When did this Joyce write that piece? Odd. Well, I hope she is in good health and spirits, in any event. George M. Carter some more links to the Hiv ccr5 treponema connection http://web.archive.org/web/20041013131900/actionlyme.com/Radolf.htm http://www.jimmunol.org/cgi/content/full/166/6/4131 http://www.jimmunol.org/cgi/content/full/169/11/6316 and much more, google for yourself >some more links to the Hiv ccr5 treponema connection > >http://web.archive.org/web/20041013131900/actionlyme.com/Radolf.htm Lyme disease is not the same as syphilis. >http://www.jimmunol.org/cgi/content/full/166/6/4131 Interesting article! This comment "Immunocytochemical and RT-PCR analyses of early syphilitic skin lesions have revealed that these infiltrating cells, as well as keratinocytes and proximal vascular endothelium, are activated and that the T cells are elaborating cytokines consistent with a Th1 response (4, 8)." underscores that HIV and syphilis are not at all the same. Sounds like syphilis antigens are the new DNCB cure for AIDS! Wheee!! >http://www.jimmunol.org/cgi/content/full/169/11/6316 > >and much more, google for yourself Ah...appears to be irrelevant to syphilis: "Haemophilus ducreyi causes the sexually transmitted disease chancroid, which facilitates HIV-1 transmission." Are you, like, insane? George M. Carter > >http://www.jimmunol.org/cgi/content/full/169/11/6316 > > > >and much more, google for yourself > > Ah...appears to be irrelevant to syphilis: "Haemophilus ducreyi ... a mistake, Haemophilus ducreyi was the causative agent of the gajdusek-nobelprize on slow viruses. TODAY in our syphilis series: we know, ccr5 is a treponema lipoprotein, so HIV-CCR5P1 is syphilis - 10 percent of all positives have it. http://www.sciencemag.org/cgi/content/abstract/282/5395/1907?ijkey=336973308adaf 24cecef64364d82d97571a05f6c&keytype2=tf_ipsecsha the 90 percent dont develop aids. why not test the hiv-tests? http://robertogiraldo.com/eng/papers/EveryoneTestsPositive.html >> >http://www.jimmunol.org/cgi/content/full/169/11/6316 >> > [quoted text clipped - 9 lines] > >we know, ccr5 is a treponema lipoprotein, What??? Who knows that?? CCR5 is a chemokine receptor. All humans, nearly, express it (with the exception of a tiny fraction delta-32 homozygous individuals). >so HIV-CCR5P1 is syphilis - 10 percent of all positives have it. > >http://www.sciencemag.org/cgi/content/abstract/282/5395/1907?ijkey=336973308adaf 24cecef64364d82d97571a05f6c&keytype2=tf_ipsecsha Says: "The CCR5 gene encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for macrophage-tropic (R5) strains of human immunodeficiency virus-type 1 (HIV-1). Genetic association analysis of five cohorts of people with acquired immunodeficiency syndrome (AIDS) revealed that infected individuals homozygous for a multisite haplotype of the CCR5 regulatory region containing the promoter allele, CCR5P1, progress to AIDS more rapidly than those with other CCR5 promoter genotypes, particularly in the early years after infection. Composite genetic epidemiologic analyses of genotypes bearing CCR5P1, CCR5-Delta 32, CCR2-64I, and SDF1-3'A affirmed distinct regulatory influences for each gene on AIDS progression. An estimated 10 to 17 percent of patients who develop AIDS within 3.5 years of HIV-1 infection do so because they are homozygous for CCR5P1/P1, and 7 to 13 percent of all people carry this susceptible genotype. The cumulative and interactive influence of these AIDS restriction genes illustrates the multigenic nature of host factors limiting AIDS disease progression." NOTHING to do with syphilis. >the 90 percent dont develop aids. >why not test the hiv-tests? > >http://robertogiraldo.com/eng/papers/EveryoneTestsPositive.html This is ancient nonsense. One interesting article: http://www.ijmm.org/archives/oct_02/orginalarticle3.htm And another on ELISA process for assessing levels of AFP: http://www.izotop.hu/immuno/ek80.htm More specifically to viral isolation: http://www.agresearch.co.nz/scied/search/tools/Elisa/index_elisa.htm a student's interesting paper: http://biomicro.sdstate.edu/WangX/MVV424524/Virological%20Methods.pdf and an interesting lecture presentation: http://courses.brown.edu/George_Yap-BI0053_F02/sschdadd7.pdf (the whole thing is interesting but around page 9, it gets into ELISAs; it also underscores that cross-reactions, discussed briefly below, are a fact of life for infections, including HIV--but it is not an argument for the non-existence of these infectious agents.) In part, the need for more serial dilutions may be due to the relatively lower induction of antibody responses in HIV infection. The level of antigen fluctuates over the course of disease and much of HIV is sequestered in lymph nodes more than in peripheral blood. In addition. the potential for cross reaction exists. Cross-reactions in the cases of certain diseases or autoimmune diseases, while an important potential confounder for an accurate diagnosis, does not serve as an argument to rule out the existence of HIV or its pathological effects. Use of serial dilution in cryptosporidiosis is described here: http://www.cdc.gov/ncidod/eid/vol7no6/eisenberg.htm From that document: ELISA Antibody assays used either a recombinant Cp23 protein or a partially purified native antigen fraction isolated from oocysts by Triton X-114 detergent extraction and were performed as described (18). Briefly, antigens were diluted in 0.1 M Na HCO3 buffer at pH 9.6 to concentrations of 0.2 µg/mL (recombinant Cp23) or 0.28 µg/mL (Triton X-114-extracted antigen) and were used to sensitize 96-well plates overnight at 4°C (50 L/well; Immunlon 2, Dynatech Industries, McLean, VA). Plates were blocked with phosphate-buffered saline (PBS) (0.85% NaCl and 10 mM Na2PO4 at pH 7.2) containing 0.3% Tween 20 for 1 hour at 4°C, then washed four times with 0.05% Tween 20/PBS. Unknown sera were diluted 1:50 in 0.05% Tween 20/PBS and loaded in duplicate (50 µL/well). Four blank wells (buffer only), duplicate wells containing three positive control sera, and duplicate wells containing four negative sera were included on each plate. A twofold serial dilution (1:50 to 1:12,800) of a strong positive control was also included on each plate to generate a standard curve. The plates were incubated for 2 hours at room temperature. Bound antibodies were quantified by using a biotinylated mouse monoclonal antibody against human IgG (1:1,000 in 0.05% Tween 20/ PBS) (clone HP6017; Zymed Laboratories, South San Francisco, CA) and alkaline phosphatase-labeled streptavidin (1:500 in 0.05% Tween 20/PBS) (Life Technologies, Rockville, MD) with p-nitrophenylphosphate substrate (Sigma Chemical Co., St. Louis, MO) as described (18). Absorbances at 405 nm were measured with a Molecular Devices UVmax kinetic microplate reader (Sunnyvale, CA). Antibody levels of unknown samples were assigned a unit value based on the 9-point positive control standard curve with a four parameter curve fit. The 1:50 dilution of the positive control serum was arbitrarily assigned a value of 6,400 U. Arbitrary unit values were expressed per microliter of serum. >And what other test will come up positive 100% of the time at a 1:1 ratio >besides HIV? First, provide a reference that ELISA at 1:1 is 100% positive in an HIV test. I have learned not to rely on such statements as they are far too often distortions or inaccurate or simply lies. Second, other tests will come up with false positive tests at a 1:1 ratio, as I previously pointed out. Whether it is 100% I have not researched, but again, clearly, for many infections, serial dilution is not uncommon and, with older ELISAs, it seems that a large number of tests come up false positive without serial dilution, depending on the antigen being sought. Add to this either repeated ELISA testing and/or a follow-up with a Western Blot, the sensitivity AND the specificity rise dramatically in evaluating an individual for HIV infection. George M. Carter ** Previously posted here: David Canzi May 7 2004, 8:02 pm show options Newsgroups: misc.health.aids Date: Sat, 8 May 2004 00:02:15 +0000 (UTC) Local: Fri, May 7 2004 8:02 pm In article <67e8de9b3199099c2844a6922e8dd...@localhost.talkabouthealthnetwork.com>, Yana <rusty4...@nospamcomcast.net> wrote: >Sure, a few times dilution is ok, but explain to me why it is necessary to >dilute 400 times for the HIV test! The following site sells ELISA test kits: <http://www.eurodiagnostica.com/catalogues/Microbiology01.pdf> Have a look at the serum dilutions they use: 1:500 for whooping cough, 1:20 for syphilis, and 1:1000 for mycoplasma pneumoneae. This doesn't explain why serum samples are so diluted for HIV testing, but it does show that there is nothing unique about the dilution used for HIV testing. We'll soon be seeing a new breed of dissident theorist disputing whether Bordetella pertussis really causes whooping cough, or even exists, right? >And what other test will come up positive 100% of the time at a 1:1 ratio >besides HIV? Funny how Giraldo didn't even try to find out, eh? ** Carlton Hogan May 10 2000, 3:00 am show options Newsgroups: misc.health.aids In article <39157a77$0$16...@reader1.casema.net>, Alex <vandee...@yahoo.com> wrote: >From: http://www.virusmyth.com/aids/data/rgelisa.htm >EVERYBODY REACTS POSITIVE >ON THE ELISA TEST FOR HIV >By Roberto Giraldo What Giraldo neatly ignores is that all of the quality control, all the assements of specificity and sensitivity, the tests of inter- and intra-measure variation, are all done on the test as it is intended to be used. So he was able to generate some anolous results by misusing the test. What does this prove? On important point to remember is that these tests are _NOT_ approved based on theory. There are stringent and detailed criteria in regards to the actual _FUNCTION_ of the test that are required. Whether the denialists like it or no, these tests have been validated, calibrated, and quality controlled using specimens of known HIV status. And by "known HIV status", I do _not_mean that EIA is validated by use of EIA. Theres's some very compelling work with HIV Cultures. "Performance characteristics of serologic tests for human immunodeficiency virus type 1 (HIV-1) antibody among Minnesota blood donors. Public health and clinical implications." MacDonald KL, Jackson JB, Bowman RJ, Polesky HF, Rhame FS, Balfour HH Jr, Osterholm MT Ann Intern Med. 1989 Apr 15;110(8):617-21. "Human immunodeficiency virus type 1 detected in all seropositive symptomatic and asymptomatic individuals" Jackson JB, Kwok SY, Sninsky JJ, Hopsicker JS, Sannerud KJ, Rhame FS, Henry K, Simpson M, Balfour HH Jr J Clin Microbiol. 1990 Jan;28(1):16-9. Carlton ** Carlton Hogan May 10 2000, 3:00 am show options Newsgroups: misc.health.aids In article <39157a77$0$16...@reader1.casema.net>, Alex <vandee...@yahoo.com> wrote: >From: http://www.virusmyth.com/aids/data/rgelisa.htm >EVERYBODY REACTS POSITIVE >ON THE ELISA TEST FOR HIV 4. Proposal to find out the real meaning of the +HIV antibody; tests. To uncover the meaning of these tests I propose a simple experiment: Take blood from three groups of a people and run the tests highly diluted, undiluted and at a wide spectrum of dilutions in between. The first group would be a group of healthy people of many age groups; the second group would be a group of people from the conventional AIDS +risk groups;; the third group would be a group of people with clinical conditions both related and unrelated to AIDS. All groups would be subjected to both the ELISA and Western Blott tests. The fact that Giraldo is unaware that such work has been done, and is published reveals his familiarity with these issues. It would also behoove him to make himself familiar with FDA's criteria for approval of diagnostic assays. Carlton >All humans, nearly, express it (with the exception of a tiny fraction delta-32 homozygous individuals). bullshit. only 10 percent of all positives have CCR5P1/P1 doubled. it comes from reverse transcription of the syphilis-cytokin ccr5 m-RNA actionlyme.org and sci.med.diseases.lyme have better antibiotics than HIV-scientists for the other 90 percent robertogiraldo.com has better treatments. >>All humans, nearly, express it (with the >exception of a tiny fraction delta-32 homozygous individuals). > >bullshit. only 10 percent of all positives have CCR5P1/P1 doubled. Ah...so what? CCR5 is not the same as CCR5 P1/P1, which is a variant. All this study (Science. 1998 Dec 4;282(5395):1907-11) suggests is that people who express this variant who have HIV have more rapid progression to AIDS. >it comes from reverse transcription of the syphilis-cytokin ccr5 m-RNA Data? T. pallidum expresses cytokines? You think CCR5 is a cytokine? >actionlyme.org and sci.med.diseases.lyme have better antibiotics than >HIV-scientists What antibiotics? I'm sure Lyme disease has all sorts of treatments to treat the distinct spirochete that causes that syndrome. >for the other 90 percent robertogiraldo.com has better treatments. What treatments? Based on what data? George M. Carter >T. pallidum expresses cytokines? You think CCR5 is a cytokine? chemokine, cytokin, interleukinXYZ, you are very intelligent George! why no CCR5P1P1-HIV-test? > What treatments? Based on what data? treponema protease inhibitors of course the syphilis ccr5 aids connection: > The CCR5-delta32 mutation: impact on disease outcome in individuals > with hepatitis C infection from a single source hep c is no disease, everybody has more ore less Hepc antibodies > The effect that this mutation may have on HCV clearance an and > severity may be not only important in relation to those solely > infected with HCV, but also of vital importance to the vast numbers > who are coinfected with HIV, hiv is no disease, everybody has more ore less hiv antibodies. see our aids myth exposed team! > particularly as anti-CCR5 directed > medications are already being investigated for the treatment of HIV. very silly to shoot at the helping chemokines. they help fighting intracellular bacteriel Th1 disease. therefore the ccr5inhibitors are very toxic! see http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=PubMed&list_uids= 10608777&dopt=Abstract "REVERSE TRANSCRIPTION-polymerase chain reaction for CCR5 gene transcripts ... revealed that either T. pallidum, ... induced CCR5 on CD14 monocytes" this detection of REVERSE TRANSCRIPTION is prove for "HIV" for the silly hiv scientists! and some p24s of course. > Methods: A total of 283 women, all exposed to HCV genotype 1b from a > single donor, what donor? strange blood with latent undetected syphilis and ebola? >and including those who had spontaneously cleared the > virus and those chronically infected, were genotyped for CCR2, CCR5, > and RANTES polymorphisms. The frequencies of these polymorphisms were > then compared with disease activity and severity. a very sh.t of paper indeed. Heterozygosity for CCR5allels is better than homozygosity for CCR5allels. what a surprise! a wide range of chemokines is always better than only 1 allel. > Conclusion: Heterozygosity for CCR5delta32 was shown to be > significantly associated with spontaneous hepatitis C viral clearance > and with significantly lower hepatic inflammatory scores in subgroups > within this cohort. as with "hiv" disease. At homozygosity for CCR5delta32 no positive hiv-test possible! but not interesting in aids-science, because we have also hiv-negative aids! >the syphilis ccr5 aids connection: >GMCarter wrote: >> The CCR5-delta32 mutation: impact on disease outcome in individuals >> with hepatitis C infection from a single source >hep c is no disease, everybody has more ore less Hepc antibodies >Provide evidence for this statement please. no more interested in aids? >> What treatments? Based on what data? > >treponema protease inhibitors of course Such exist? Please share. >the syphilis ccr5 aids connection: > >> The CCR5-delta32 mutation: impact on disease outcome in individuals >> with hepatitis C infection from a single source > >hep c is no disease, everybody has more ore less Hepc antibodies What data is this claim based upon? >hiv is no disease, everybody has more ore less hiv antibodies. >see our aids myth exposed team! What data is this claim based upon? >> particularly as anti-CCR5 directed >> medications are already being investigated for the treatment of HIV. > >very silly to shoot at the helping chemokines. they help fighting >intracellular bacteriel Th1 disease. >therefore the ccr5inhibitors are very toxic! Ah--I thought you were the one suggesting them just last week.... snip >this detection of REVERSE TRANSCRIPTION is prove for "HIV" for the >silly hiv scientists! and some p24s of course. No-you are silly. The statement above is false. >> Methods: A total of 283 women, all exposed to HCV genotype 1b from a >> single donor, > >what donor? strange blood with latent undetected syphilis and ebola? Undoubtedly someone who consumed quantities of lunar green cheese. snip... >as with "hiv" disease. At homozygosity for CCR5delta32 no positive >hiv-test possible! Incorrect. CCR5delta32 reduces the risk of HIV infection but does not eliminate it. What language did you grow up speaking? George M. Carter GMSpammer wrote >>> particularly as anti-CCR5 directed >>> medications are already being investigated for the treatment of HIV. >>very silly to shoot at the helping chemokines. they help fighting >>intracellular bacteriel Th1 disease. >>therefore the ccr5inhibitors are very toxic! >>see >>http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=PubMed&list_uids= 10608777&dopt=Abstract >>"REVERSE TRANSCRIPTION-polymerase chain reaction for CCR5 >>gene >>transcripts ... revealed that either T. pallidum, ... induced CCR5 on >>CD14 monocytes" >Ah--I thought you were the one suggesting them just last week.... this is all you have to say about killing hiv-patients with chemokine terminators? >this is all you have to say about killing hiv-patients with >chemokine terminators? you won't answer any questions I raise? why are you still beating your wife? >>>http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=PubMed&list_uids= 10608777&dopt=Abstract You really have no clue about what you post here, do you? George M. Carter ** Sellati TJ, Wilkinson DA, Sheffield JS, Koup RA, Radolf JD, Norgard MV. Virulent Treponema pallidum, lipoprotein, and synthetic lipopeptides induce CCR5 on human monocytes and enhance their susceptibility to infection by human immunodeficiency virus type 1. J Infect Dis. 2000 Jan;181(1):283-93. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Treponema pallidum, its membrane lipoproteins, and synthetic lipoprotein analogues (lipopeptides) were each examined to determine whether they induced CCR5 expression on human peripheral blood mononuclear cells (PBMC). Reverse transcription-polymerase chain reaction for CCR5 gene transcripts, macrophage inflammatory protein (MIP)-1beta binding assays, and flow cytometry revealed that either T. pallidum, a representative treponemal lipoprotein, or a corresponding synthetic lipopeptide induced CCR5 on CD14 monocytes but not on CD3 lymphocytes. CXCR4, the coreceptor for T cell-tropic strains of human immunodeficiency virus type 1 (HIV-1), was not induced on PBMC by treponemes or by lipoproteins or lipopeptides. Consistent with these findings, T. pallidum, lipoprotein, and synthetic lipopeptide all promoted the entry of a macrophage-tropic, but not a T cell-tropic, strain of HIV-1 into monocytes. These combined results imply that T. pallidum and its constituent lipoproteins likely induce the expression of CCR5 on macrophages in syphilitic lesions, thereby enhancing transmission of macrophage-tropic HIV-1. > These combined results imply that T. > pallidum and its constituent lipoproteins likely induce the expression > of CCR5 on macrophages in syphilitic lesions, thereby enhancing > transmission of macrophage-tropic HIV-1. Oh...George! Please dont get confused with this alphanumeric string "HIV-1" in this complicated text! This is only a silly game scientists play all the time to confuse each other. they are only kidding! no problem? see http://www.colman.net video 3 and 4 >> These combined results imply that T. >> pallidum and its constituent lipoproteins likely induce the expression [quoted text clipped - 6 lines] >This is only a silly game scientists play all the time to confuse >each other. they are only kidding! no problem? I see. You post a URL to an abstract that is supposed to support your very unclear point and then say the AUTHORS were just kidding. Ah....I think I know who is really kidding. George M. Carter > >>All humans, nearly, express it (with the > >exception of a tiny fraction delta-32 homozygous individuals). > > > >bullshit. only 10 percent of all positives have CCR5P1/P1 doubled. > > Ah...so what? CCR5 is not the same as CCR5 P1/P1, which is a variant. no George, ccr5 p1/p1 is no "variant" of ccr5. TODAY in our syphilis is aids series: gallo and his endogenous p24-ccr5-hiv isolates: "Then they mixed lymphocytes from patients in "high-risk groups" with exceptionally rapidly dividing leukaemia cells (3,4). This cell mixture was then subjected to the effects of certain biochemical substances. They go on to say that "in vitro stimulation was achieved by mitogens or added cells (allogenic antigens ) ... Certain manipulation of culture conditions improved the result, for example, co-cultivation of patients' cells with peripheral white blood cells, which were stimulated by mitogens, from non-infected donors. The "virus isolation" of cultured cells was also significantly facilitated by adding hydrocortisone to the culture medium" from http://aids-info.net/micha/hiv/aids/kremergalengl.html because of the cortisone stimulation of gallo "CCR5 progresses through the endoplasmic reticulum prior to appearing on the cell surface" http://www.jbc.org/cgi/content/abstract/272/49/30603?ijkey=534fcd9c85b3068558799 cb79cbdd394ecb3e633&keytype2=tf_ipsecsha the only cadidate for surfacing ccr5 receptors on cell walls is p24: http://www.pnas.org/cgi/content-nw/full/97/8/3783/F2 and http://www.pnas.org/cgi/content/full/97/8/3783?ijkey=151f5c1383813764ac27c9d402e 2ce690491fe28&keytype2=tf_ipsecsha so, we have a HIV-test, which tracks late stage syphilis very good, but, unfortunately, also tracks healthy individuals, like magic johnson, christine maggiore and http://www.kimbannon.com snip...> >> Ah...so what? CCR5 is not the same as CCR5 P1/P1, which is a variant. > >no George, ccr5 p1/p1 is no "variant" of ccr5. What you write below does not support this statement. snip >because of the cortisone stimulation of gallo What evidence do you have of this? >"CCR5 progresses through the endoplasmic reticulum prior to appearing >on the cell surface" What do you think is the meaning of the expression of CCR5? >http://www.jbc.org/cgi/content/abstract/272/49/30603?ijkey=534fcd9c85b3068558799 cb79cbdd394ecb3e633&keytype2=tf_ipsecsha The title of which is "Mechanism of Transdominant Inhibition of CCR5-mediated HIV-1 Infection by ccr5Delta 32" Nothing to do with syphilis. Instructive to read the whole article, but here's the abstract: "Human chemokine receptor 5 (CCR5) functions as a co-receptor for Human immunodeficiency virus (HIV-1) infection. CCR5 is a seven-transmembrane cell surface receptor. Recently, a naturally occurring mutation of CCR5, ccr5Delta 32, has been described. A small number of Caucasians are homozygously ccr5Delta 32/ccr5Delta 32, while a larger number of individuals are heterozygously CCR5/ccr5Delta 32. The ccr5Delta 32/ccr5Delta 32 genotype has been linked to a phenotype that is "highly" protected from HIV-1 infection. On the other hand, several studies have shown that the CCR5/ccr5Delta 32 genotype confers "relative" protection from AIDS with onset of disease being delayed by 2-4 years. Although it is known that peripheral blood lymphocytes from heterozygous individuals (CCR5/ccr5Delta 32) support ex vivo HIV-1 replication at a reduced level compared with CCR5/CCR5 cells, the molecular basis for this observation is unknown. Here we report on events that post-translationally modify CCR5. We show that CCR5 progresses through the endoplasmic reticulum prior to appearing on the cell surface. Mature CCR5 can be post-translationally modified by phosphorylation and/or co-translationally by multimerization. By contrast, mutant ccr5Delta 32, although retaining the capacity for multimerization, was incapable of being phosphorylated. ccr5Delta 32 heterocomplexes with CCR5, and this interaction retains CCR5 in the endoplasmic reticulum resulting in reduced cell surface expression. Thus, co-expression in cells of ccr5Delta 32 with CCR5 produces a trans-inhibition by the former of ability by the latter to support HIV-1 infection. Taken together, our findings suggest CCR5/ccr5Delta 32 heterodimerization as a molecular explanation for the delayed onset of AIDS in CCR5/ccr5Delta 32 individuals." >the only cadidate for surfacing ccr5 receptors on cell walls is p24: > >http://www.pnas.org/cgi/content-nw/full/97/8/3783/F2 Not sure what p24 is meant to indicate here. >and >http://www.pnas.org/cgi/content/full/97/8/3783?ijkey=151f5c1383813764ac27c9d402e 2ce690491fe28&keytype2=tf_ipsecsha They note: "Thinking about p24 proteins and how transport vesicles select their cargo" "The p24 proteins are a conserved family of small integral membrane proteins found in eukaryotes from yeast to mammals. These proteins were first identified as abundant constituents of the COPI and COPII vesicles that operate in the early secretory pathway (10-12). (COPI vesicles carry proteins between the cisternae of the Golgi complex and from the Golgi to the ER, whereas COPII vesicles carry proteins from the ER to the Golgi.)" As others have pointed out, this is apples and cauliflowers kind of comparison. Have you done a BLAST search to show they're identical? Might help your case! >so, we have a HIV-test, which tracks late stage syphilis very good, Does it? How so? >but, unfortunately, also tracks healthy individuals, >like magic johnson, christine maggiore and http://www.kimbannon.com Another denialist. Does not support the case that "syphilis=AIDS" that you attempt to argue. George M. Carter <snip> > As others have pointed out, this is apples and cauliflowers kind of > comparison. Have you done a BLAST search to show they're identical? > Might help your case! I have a few hundred CDs. They all weigh the same therefore they are the same. There is no possible way to tell them apart. Chris Noble > >"CCR5 progresses through the endoplasmic reticulum prior to appearing > >on the cell surface" > > What do you think is the meaning of the expression of CCR5? here you have it: "REVERSE TRANSCRIPTION-polymerase chain reaction for CCR5 gene transcripts ... revealed that either T. pallidum, ... induced CCR5 on CD14 monocytes" http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=PubMed&list_uids= 10608777&dopt=Abstract > The title of which is "Mechanism of Transdominant Inhibition of > CCR5-mediated HIV-1 Infection by ccr5Delta 32" Nothing to do with > syphilis. T. pallidum has nothing to do with syphilis? > Instructive to read the whole article, but here's the abstract: > > "Human chemokine receptor 5 (CCR5) functions as a co-receptor for > Human immunodeficiency virus (HIV-1) infection. this is only current dogma. you dont get your paper published without this sentence. "The ccr5Delta 32/ccr5Delta 32 genotype has been linked to a phenotype that is "highly" protected from HIV-1 infection" these genotypes never get a positive endogenous gallo-test, because the original montagnier patients, from where gallo has stolen his tests, were not of this genotype. but this genotype doesnt protect from an aids-infection. patients with this genotype would fight their treponemas with other chemokines, for example ccr2. > >the only cadidate for surfacing ccr5 receptors on cell walls is p24: > > > >http://www.pnas.org/cgi/content-nw/full/97/8/3783/F2 > > Not sure what p24 is meant to indicate here. there you see your "hiv-isolates", all people are hiv-positive, (see robertogiraldo.com) except of course the double ccr5delta32 genotypes. > >and > >http://www.pnas.org/cgi/content/full/97/8/3783?ijkey=151f5c1383813764ac27c9d402e 2ce690491fe28&keytype2=tf_ipsecsha [quoted text clipped - 13 lines] > comparison. Have you done a BLAST search to show they're identical? > Might help your case! dear george, you must have some sh.t in your brain! go blast your sh.t. > >so, we have a HIV-test, which tracks late stage syphilis very good, > > Does it? How so? patients get vdrl-negative, but stay hiv-positive. see colman.net video 3 and 4 > >but, unfortunately, also tracks healthy individuals, > >like magic johnson, christine maggiore and http://www.kimbannon.com >> >"CCR5 progresses through the endoplasmic reticulum prior to appearing >> >on the cell surface" [quoted text clipped - 8 lines] > >http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=PubMed&list_uids= 10608777&dopt=Abstract Not in the slightest. Indeed, they note that "CXCR4, the coreceptor for T cell-tropic strains of human immunodeficiency virus type 1 (HIV-1), was not induced on PBMC by treponemes or by lipoproteins or lipopeptides." R5 may be induced by syphilis which may in turn enhance HIV infection. But this doesn't make the case for syphilis = AIDS. To the contrary. It refutes it by noting the fact HIV may also use X4 receptors, which are generally associated with syncytia-inducing viruses and, clinically, with more rapid progression. >> The title of which is "Mechanism of Transdominant Inhibition of >> CCR5-mediated HIV-1 Infection by ccr5Delta 32" Nothing to do with >> syphilis. > >T. pallidum has nothing to do with syphilis? Is that what you think? >> Instructive to read the whole article, but here's the abstract: >> [quoted text clipped - 6 lines] > "The ccr5Delta 32/ccr5Delta 32 genotype has been linked to a phenotype >that is "highly" protected from HIV-1 infection" I see. So if there is evidence that conflicts with your theory, it is "dogma"? What? Delta-32 R5 phenotypes, esp. homozygous expression, are more resistant to HIV infection: you dispute those findings? If so, why? That does NOT mean immune to HIV infection. >these genotypes never get a positive endogenous gallo-test, >because the original montagnier patients, from where gallo >has stolen his tests, were not of this genotype. What????? This is wrong. "Never" is inaccurate. And what does R5-delta32 have to do with syphilis? >but this genotype doesnt protect from an aids-infection. >patients with this genotype would fight their treponemas >with other chemokines, for example ccr2. It might. Doesn't mean AIDS=syphilis. >> >the only cadidate for surfacing ccr5 receptors on cell walls is p24: >> > [quoted text clipped - 5 lines] >(see robertogiraldo.com) except of course the double ccr5delta32 >genotypes. Ah--HIV tests aren't for p24 alone, you know? >> >and >> >http://www.pnas.org/cgi/content/full/97/8/3783?ijkey=151f5c1383813764ac27c9d402e 2ce690491fe28&keytype2=tf_ipsecsha [quoted text clipped - 16 lines] >dear george, you must have some sh.t in your brain! >go blast your sh.t. Wow. OK. That's a brilliant answer. Apparently, either you HAVE done the search and found nothing or you haven't and you're just lazy. Or incompetent. Feh. Troll. George M. Carter GMSpammer wrote: > >these genotypes never get a positive endogenous gallo-test, > >because the original montagnier patients, from where gallo > >has stolen his tests, were not of this genotype. > > What????? Not understanding this simple sentence? Oh George, you are at great risk of neurosyphilis. TODAY in our syphilis is aids series A SPECIAL FEATURE for our censored "AIDS myth exposed" team What is the pathogenic difference between (Huw Christie, Pasquarelli, Leroy Whitfield, ...) and (Magic Johnson, C. Maggiore, kimbannon.com, ...)???? Syphilis? the answer is yes. But penicillin would have cured it? the answer is no. penicillin never cured syphilis. with syphilis your maximum lifetime is 40. reinfections do trigger this limit downwards. but syphilis does not behave like a leftist? the answer is yes. >GMSpammer wrote: > [quoted text clipped - 6 lines] >Not understanding this simple sentence? >Oh George, you are at great risk of neurosyphilis. Try writing it in your native language. GMSpammer wrote: > >GMSpammer wrote: > > [quoted text clipped - 8 lines] > > Try writing it in your native language. o.k. kosh kolly gee > >GMSpammer wrote: > > [quoted text clipped - 6 lines] > >Not understanding this simple sentence? > >Oh George, you are at great risk of neurosyphilis. TODAY in our syphilis is aids series A SPECIAL FEATURE for our censored "AIDS myth exposed" team What is the pathogenic difference between (Huw Christie, Pasquarelli, Leroy Whitfield, ...) and (Magic Johnson, C. Maggiore, kimbannon.com, ...)???? Syphilis? the answer is yes. But penicillin would have cured it? the answer is no. penicillin never cured syphilis. with syphilis your maximum lifetime is 40. reinfections do trigger this limit downwards. but syphilis does not behave like a leftist? the answer is yes. snip >the answer is no. penicillin never cured syphilis. If English is your native language, I'm worried. Now--why did you refer me previously to a URL that claimed to have all the answers and a good treatment--which was penicillin? >with syphilis your maximum lifetime is 40. You have no data for this. It is utterly ridiculous. Sigh. You MUST be a troll. George M. Carter Hi George! do you like these videos? http://www.colman.net video 3 and 4 TODAY in our AIDS series: Condoms dont protect from Syphilis-AIDS, because Syphilis is highly infectious. >Hi George! > [quoted text clipped - 4 lines] >Condoms dont protect from Syphilis-AIDS, >because Syphilis is highly infectious. Then why isn't there a LOT more cases of AIDS? And what does that mean? Abandon condoms? Or abandon sex altogether? I'm sure that would warm the hypocritical frozen cockles of the xtian taliban! "GMCarter" <fiar@verizon.net> wrote in message > Then why isn't there a LOT more cases of AIDS? Not everyone engages in behavior that spreads aids. My opinion has not infected anyone with hiv/aids. "GMCarter" <fiar@verizon.net> wrote in message > Then why isn't there a LOT more cases of AIDS? faggotry (causes) aids, the virus is the (result) of that perversion. Penicillin didn't cause syphilis. > "GMCarter" <fiar@verizon.net> wrote in message >> >> Then why isn't there a LOT more cases of AIDS? >> > faggotry (causes) aids, the virus is the (result) of that perversion. Since the vast majority of people with AIDS/HIV in the world are heterosexual, Death remains in denial of the fact that most of the deadly perversions on the planet are heterosexual in nature. That includes wars, abortions and other forms of homicide. Now who has fewer abortions that homosexuals? susie "Susie, age 9" <nomail@noway.com> wrote in message > "Death" <Death@yourdoor.net> wrote in message > > [quoted text clipped - 8 lines] > most of the deadly perversions on the planet are heterosexual > in nature. Not when you eliminate the down low niggers from those stats. > That includes wars, abortions and other forms of homicide. > > Now who has fewer abortions that homosexuals? You abort a turd every time you take a dump. Talk about dead beat dads. > "Susie, age 9" <nomail@noway.com> wrote in message >> [quoted text clipped - 12 lines] > > Not when you eliminate the down low niggers from those stats. I did, Death. I'm sure that even YOU could appreciate the low abortion rate among descendant Africans, or for that matter, trailer court Caucasians. And WHO started an illegal war in Iraq? >> That includes wars, abortions and other forms of homicide "Susie, age 9" <nomail@noway.com> wrote in message > And WHO started an illegal war in Iraq? Yep, it's just like the World Health Org. to pull that faggot stunt. Over con-dumbs properly. > "Susie, age 9" <nomail@noway.com> wrote in message >> >> And WHO started an illegal war in Iraq? >> > Yep, it's just like the World Health Org. to pull that faggot stunt. > Over con-dumbs properly. FIAR = condoms for Nepal (see George M. Carter for details about donating to his tax-deductible non-profit organization "FIAR") "Susie, age 9" <nomail@noway.com> wrote in message > (see George M. Carter for details about donating to his > tax-deductible non-profit organization "FIAR") I wish I made as much money as the non-profit companies >"Susie, age 9" <nomail@noway.com> wrote in message >> >> (see George M. Carter for details about donating to his >> tax-deductible non-profit organization "FIAR") >> >I wish I made as much money as the non-profit companies LOL. I guess that's why you spend so much time here...unemployed? That's probably more lucrative than my income in many areas of the U.S. Susie-Frod. Stuff it or you'll work yourself into a tizzy and wind up violating your parole again. George M. Carter "GMCarter" <fiar@verizon.net> wrote in message > LOL. I guess that's why you spend so much time here...unemployed? That is a fact, no one hired me, but people are dying for my services. >That's probably more lucrative than my income in many areas of the >U.S. I hate to hear that, Charon requires coins. >"GMCarter" <fiar@verizon.net> wrote in message > >> LOL. I guess that's why you spend so much time here...unemployed? > >That is a fact, no one hired me, but people are dying for my services. Darling, you are not death. You're just an ordinary fool who will one day meet his own end...and I wonder if you'll regret all the time you spent filling your mind with hate? "GMCarter" <fiar@verizon.net> wrote in message > "Death" <Death@yourdoor.net> > > [quoted text clipped - 5 lines] > > , you are not death. ... Really !, are you sure ? LOL > LOL. I guess that's why you spend so much time here...unemployed? So George now admits he is employed (by inference). George Mary also admits he is the Director of FIAR. Therefore, George Mary is employed by FIAR, a non-profit tax-deductible charity - set up by George Mary FOR George Mary ... and something to do with handing out condoms to Nepalese sherpas. susie >> LOL. I guess that's why you spend so much time here...unemployed? > [quoted text clipped - 6 lines] >... and something to do with handing out condoms to >Nepalese sherpas. First, that's wrong. I do not receive an income from FIAR. I hope to some day as that will mean it is much better endowed. Second, we do not supply Nepali sherpas with condoms per se. In fact, the condom distribution program is primarily targeted to men who have sex with men. This was the idea of my friend Sunil. Third, if Sherpas want to use condoms--great! I'd be happy to help them obtain condoms. Whether for having same or opposite sex relations. George M. Carter >>> LOL. I guess that's why you spend so much time here...unemployed? >> [quoted text clipped - 8 lines] > > First, that's wrong. I do not receive an income from FIAR. I said nothing about you receiving income from FIAR. > Second, we do not supply Nepali sherpas with condoms per se. > In fact, the condom distribution program is primarily targeted to > men who have sex with men. Sherpas are men who have sex with men, on occasion. Its lonely on that Sherpa mountain trail, as you well know. > This was the idea of my friend Sunil. Sherpa Sunil. > Third, if Sherpas want to use condoms--great! I'd be happy to help > them obtain condoms. Whether for having same or opposite sex > relations. Sherpas need condoms mostly to put things in so they stay dry. Perhaps you need to distribute zip-lock bags instead. LOL! sherpa susie >>>> LOL. I guess that's why you spend so much time here...unemployed? >>> [quoted text clipped - 10 lines] > >I said nothing about you receiving income from FIAR. Wow...like "employed" doesn't entail an income? In what odd lexicon? >> Second, we do not supply Nepali sherpas with condoms per se. >> In fact, the condom distribution program is primarily targeted to >> men who have sex with men. > >Sherpas are men who have sex with men, on occasion. Its lonely >on that Sherpa mountain trail, as you well know. Sure. >> This was the idea of my friend Sunil. > >Sherpa Sunil. Nope. Not his family name. There are many different families in Nepal. >> Third, if Sherpas want to use condoms--great! I'd be happy to help >> them obtain condoms. Whether for having same or opposite sex >> relations. > >Sherpas need condoms mostly to put things in so they stay dry. Really. Interesting. I've never heard of condoms being used that way. Of course, you'll have a reference, no doubt. Please provide it! >Perhaps you need to distribute zip-lock bags instead. They have those in Kathmandu. They're not part of HIV prevention programs. George M. Carter >>Sherpa Sunil. > > Nope. Not his family name. There are many different families in Nepal. Sherpa isn't a family name, you idiot. For someone who purports to be the Director of a non-profit tax-deductible charity directed towards the needs of Nepalese, you obviously don't know sh.t about the culture! >>Perhaps you need to distribute zip-lock bags instead. > > They have those in Kathmandu. They're not part of HIV prevention > programs. Well they would be if they put them over their heads! LOL ! susie >>>Sherpa Sunil. >> >> Nope. Not his family name. There are many different families in Nepal. > >Sherpa isn't a family name, you idiot. You're literalism doesn't merely verge on the idiotic, dear. >>>>Sherpa Sunil. >>> [quoted text clipped - 3 lines] > > You're literalism doesn't merely verge on the idiotic, dear. No that would be your ignorance screaming for help. susie >> You're literalism doesn't merely verge on the idiotic, dear. > >No that would be your ignorance screaming for help. We all can use help. You even help me. Not with the specifics of course, but rather with understanding the mind of an angry, hurt sad person. Indeed, I could point out that your recent admission that ARV works for people with AIDS is a sign that you are a "PHARMA SHILL" pushing drugs on hapless people. And that this makes you anathema to people like Paul and wilyretrovirus and montygram! Gosh. It's only returning your own marvelous logic to you. But that viciousness and ugliness is yours to bear. George M. Carter >>> You're literalism doesn't merely verge on the idiotic, dear. >> [quoted text clipped - 3 lines] > course, but rather with understanding the mind of an angry, hurt sad > person. And don't forget the true love behind my sad words... > Indeed, I could point out that your recent admission that ARV works > for people with AIDS is a sign that you are a "PHARMA SHILL" pushing > drugs on hapless people. And that this makes you anathema to people > like Paul and wilyretrovirus and montygram! Gosh. Anathema aside, I speaketh the truth... shillith or not. > It's only returning your own marvelous logic to you. And greedily accepteth. > But that viciousness and ugliness is yours to bear. Fa la la la la ... la la la la... don we now our gay apparel.... susie >>>> You're literalism doesn't merely verge on the idiotic, dear. >>> [quoted text clipped - 12 lines] > > Anathema aside, I speaketh the truth... shillith or not. What happened to the 'truth' you used to speak about DNCB? Gary Stein "Susie, age 9" <nomail@noway.com> wrote in message > Fa la la la la ... la la la la... don we now our gay apparel.... Indeed happy clothes are worn at Christmas. Put on your best dress and shoes. It is snowing outside, best include pantyhose. You couldn't pick up a faggot with frozen chestnuts. >And don't forget the true love behind my sad words... It is never far from my mind, my poor dear. >>And don't forget the true love behind my sad words... > > It is never far from my mind, my poor dear. No different than those sherpa-condomizing fantasies that dance in your little pointy head, sweetie. susie http://www.robertbenmitchell.com/books/saa/ One of my favorite AIDS books is Syphilis As Aids by Robert Ben Mitchell, [out of print, and not on most of the book lists]. Along with much other vital data, he points out two VERY interesting pieces of information. 1] If you have PCP pneumonia, YOU HAVE SYPHILIS! 2] If you have Karposi's Sarcoma, YOU HAVE SYPHILIS! They are two if the KEY diagnostic indicators which PROVE the presence of syphilis. When did we find this out? About 1850! So we've known these facts for 150 years now . . . but we don't talk about them any more. Why not? It's not politicallies co-rectum! We don't treat dying people for the syphilis they have, because NOW we have a better idea: we treat them for a hallucinatory disease they don't have, with a "treatment" [fatal-in-itself] which guarantees to destroy their immune systems and let the syphilis doubly kill them, thereby proving the doctor's sanctimonious pronouncements that they had a "fatal disease." Isn't progress wonderful? Or how about this? The spongy rotted-out brain condition that used to be know as "tertiary syphilis" is now referred to as "aids dementia." Completely unfounded fad propaganda medicine creates wrong diagnosis which causes wrong treatment and certain death. Another medical breakthrough! Ah--I didn't write any of that. > Ah--I didn't write any of that. Ohh, was it from Susie? http://www.robertbenmitchell.com/books/saa/ "One of my favorite AIDS books is Syphilis As Aids by Robert Ben Mitchell, [out of print, and not on most of the book lists]. Along with much other vital data, he points out two VERY interesting pieces of information. 1] If you have PCP pneumonia, YOU HAVE SYPHILIS! 2] If you have Karposi's Sarcoma, YOU HAVE SYPHILIS! They are two if the KEY diagnostic indicators which PROVE the presence of syphilis. When did we find this out? About 1850! So we've known these facts for 150 years now . . . but we don't talk about them any more. Why not? It's not politicallies co-rectum! We don't treat dying people for the syphilis they have, because NOW we have a better idea: we treat them for a hallucinatory disease they don't have, with a "treatment" [fatal-in-itself] which guarantees to destroy their immune systems and let the syphilis doubly kill them, thereby proving the doctor's sanctimonious pronouncements that they had a "fatal disease." Isn't progress wonderful? Or how about this? The spongy rotted-out brain condition that used to be know as "tertiary syphilis" is now referred to as "aids dementia." Completely unfounded fad propaganda medicine creates wrong diagnosis which causes wrong treatment and certain death. Another medical breakthrough! " >> Ah--I didn't write any of that. > >Ohh, was it from Susie? Does it matter? Fred spouts about as much crap as you do. > >> Ah--I didn't write any of that. > > > >Ohh, was it from Susie? > > Does it matter? Fred spouts about as much crap as you do. spouts with the mouth? treponema denticola? > > >> Ah--I didn't write any of that. > > > [quoted text clipped - 3 lines] > > spouts with the mouth? treponema denticola? http://www.actionlyme.org/ and http://autoimmunityresearch.org/trevor-30th.ram spirochete science is free of HIV-science-Madness: > http://www.actionlyme.org/ or > http://autoimmunityresearch.org/trevor-30th.ram where Dr. Marshall shows the Th1/Th2 shift (because of your syphilis cysts, or toxins) > Third, if Sherpas want to use condoms--great! dangerous! second stage aids spreads through the mouth. TODAY in our SYPHILIS is AIDS series 1. The hiv-test is the best test to detect latent syphilis 2. the sensitivity of the hiv-test was also triggered to detect iv drug use; the gallo freaks feared robbing junkies. (sharing needle theory is a myth-sh.t) 3. everybody reacts positive with undiluted blood. Thank you all for keeping my thread running! "GMCarter" <f...@verizon.net> wrote in message news:f0rip15mp4oebpumrnu2etu95f08obnqdr@4ax.com... > On Thu, 8 Dec 2005 15:39:52 -0500, "Susie, age 9" <nom...@noway.com> > wrote: >>And don't forget the true love behind my sad words... > It is never far from my mind, my poor dear. No different than those sherpa-condomizing fantasies that dance in your little pointy head, sweetie. susie Susie, you are minimum 10! AIDS solved - Syphilis living in white blood cells resists treatment > >Hi George! > > [quoted text clipped - 6 lines] > > Then why isn't there a LOT more cases of AIDS? the second wave after the 80s is coming. wait some time. >>we know, ccr5 is a treponema lipoprotein, > > What??? Who knows that?? "tall and tan and young and lovely, the girl from Treponema goes walking..." B/ > CCR5 is a chemokine receptor. All humans, nearly, express it (with the > exception of a tiny fraction delta-32 homozygous individuals). [quoted text clipped - 219 lines] > > Carlton >>>we know, ccr5 is a treponema lipoprotein, >> >> What??? Who knows that?? > >"tall and tan and young and lovely, the girl from Treponema goes walking..." More "corkscrewing" along.... No. Hulda Clark has already solved AIDS. http://www.drclark.net/hiv/hiv_start.htm Chris Noble > No. > Hulda Clark has already solved AIDS. > http://www.drclark.net/hiv/hiv_start.htm > > Chris Noble good joke. dont wanna talk about syphilis? wanna talk about the quantitative hiv-goldstandard-p24-test, about the many p24s from the human golgi apparatus in liver cells? Belden, W.J., and C. Barlowe. 1996. Erv25p, a component of COPII-coated vesicles, forms a complex with Emp24p that is required for efficient endoplasmic reticulum to Golgi transport. J Biol Chem. 271:26939-26946. Belden, W.J.u.B., C. 2001. Distinct Roles for the Cytoplasmic Tail Sequences of Emp24p and Erv25p in Transport between the Endoplasmatic Reticulum and Golgi Complex. JBC. in press. Blum, R., P. Feick, M. Puype, J. Vandekerckhove, R. Klengel, W. Nastainczyk, and I. Schulz. 1996. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. J Biol Chem. 271:17183-17189. Blum, R., F. Pfeiffer, P. Feick, W. Nastainczyk, B. Kohler, K.H. Schafer, and I. Schulz. 1999. Intracellular localization and in vivo trafficking of p24A and p23. J Cell Sci. 112:537-548. Denzel, A., F. Otto, A. Girod, R. Pepperkok, R. Watson, I. Rosewell, J.J. Bergeron, R.C. Solari, and M.J. Owen. 2000. The p24 family member p23 is required for early embryonic development. Curr Biol. 10:55-58. Dominguez, M., K. Dejgaard, J. Fullekrug, S. Dahan, A. Fazel, J.P. Paccaud, D.Y. Thomas, J.J. Bergeron, and T. Nilsson. 1998. gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. J Cell Biol. 140:751-65. Emery, G., Grünberg, J. und Rojo, M. 1999. The p24 family of transmembrane proteins at the interface between endoplasmatic reticulum and Golgi apparatus. Protoplasma. 207:24-30. Emery, G., M. Rojo, and J. Gruenberg. 2000. Coupled transport of p24 family members. J Cell Sci. 113:2507-2516. Fiedler, K., M. Veit, M.A. Stamnes, and J.E. Rothman. 1996. Bimodal interaction of coatomer with the p24 family of putative cargo receptors. Science. 273:1396- 9. Füllekrug, J., T. Suganuma, B.L. Tang, W. Hong, B. Storrie, and T. Nilsson. 1999. Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Mol Biol Cell. 10:1939-1955. Gommel, D., L. Orci, E.M. Emig, M.J. Hannah, M. Ravazzola, W. Nickel, J.B. Helms, F.T. Wieland, and K. Sohn. 1999. p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form heterooligomeric complexes and cycle between the organelles of the early secretory pathway. FEBS Lett. 447:179-185. Kaiser, C. 2000. Thinking about p24 proteins and how transport vesicles select their cargo. Proc Natl Acad Sci U S A. 97:3783-3785. Kuiper, R.P., G. Bouw, K.P. Janssen, J. Rotter, F. van Herp, and G.J. Martens. 2001. Localization of p24 putative cargo receptors in the early secretory pathway depends on the biosynthetic activity of the cell. Biochem J. 360:421-9. Marzioch, M., D.C. Henthorn, J.M. Herrmann, R. Wilson, D.Y. Thomas, J.J. Bergeron, R.C. Solari, and A. Rowley. 1999. Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Mol Biol Cell. 10:1923-1938. Muniz, M., C. Nuoffer, H.P. Hauri, and H. Riezman. 2000. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles. J Cell Biol. 148:925-930. Schimmoller, F., B. Singer-Kruger, S. Schroder, U. Kruger, C. Barlowe, and H. Riezman. 1995. The absence of Emp24p, a component of ER-derived COPIIcoated vesicles, causes a defect in transport of selected proteins to the Golgi. Embo J. 14:1329-1339. Springer, S., E. Chen, R. Duden, M. Marzioch, A. Rowley, S. Hamamoto, S. Merchant, and R. Schekman. 2000. The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 97:4034-4039. online book "Syphilis as AIDS" http://www.robertbenmitchell.com/books/saa/ Nietzsche and AIDS http://www.amacad.org/publications/fall2004/margulis.pdf
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