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Medical Forum / Diseases and Disorders / AIDS / June 2005

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Condom cancer risk exposed

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PaulKing - 22 Jun 2005 20:25 GMT
Condom cancer risk exposed

Most condoms contain a cancer-causing chemical and their manufacture
should be subject to greater quality control, a German scientific research
institute said.

The Chemical and Veterinary Investigation Institute in Stuttgart, Germany,
said it found the carcinogen N-Nitrosamine present in 29 of 32 types of
condoms it tested in simulated conditions.

"N-Nitrosamine is one of the most carcinogenic substances," the study's
authors said.
"There is a pressing need for manufacturers to tackle this problem."
The carcinogen is thought to be present in a substance used to improve
condom elasticity.
When the rubber material comes in contact with human bodily fluids, it can
release traces of N-Nitrosamine, the study said.
Local government officials said condom users should not stop using rubber
contraceptives based on results of the study because N-Nitrosamine does
not present an immediate health danger.

Germany's Federal Institute for Risk Assessment said that daily condom use
exposed users to N-Nitrosamine levels up to three times higher than levels
naturally present in food.

-- Reuters
GMCarter - 22 Jun 2005 22:15 GMT
>Condom cancer risk exposed

What risk? And again, the data that exist refute this. Previously
posted.

Geez, Paul-Mark-thing, can't you come up with anything new?

        George M. Carter
PaulKing - 23 Jun 2005 11:00 GMT
"and again, the data that exist refute this."

No such data exists and you have failed to provide any.

Once again we get Carter lies and silly insults.

What a pathetic character you are.
GMCarter - 23 Jun 2005 23:02 GMT
>"and again, the data that exist refute this."
>
>No such data exists and you have failed to provide any.

Either you never read it or you did and you're just lying. I've posted
the Proksch data frequently.

I'll repeat it and add some.

    George M. Carter

**
Condoms can PREVENT certain cancers:

Bleeker MC, Hogewoning CJ, Voorhorst FJ, van den Brule AJ, Snijders
PJ, Starink TM, Berkhof J, Meijer CJ. Condom use promotes regression
of human papillomavirus-associated penile lesions in male sexual
partners of women with cervical intraepithelial neoplasia. Int J
Cancer. 2003 Dec 10;107(5):804-10.

Department of Pathology, VU University Medical Center, Amsterdam, the
Netherlands.

   Penile HPV-associated lesions are frequently seen in male sexual
partners of women with CIN. The natural course and clinical
significance of these lesions are unclear. Women with CIN and their
male sexual partners were randomized for condom use (condom group n =
68, noncondom group n = 68). Males were screened for the presence of
penile lesions, i.e., flat lesions, papular lesions and condylomata
acuminata, and of HPV in their penile swabs by PCR testing. Median
follow-up time was 13.1 months (range 2.9-57.4). The outcome of our
study was clinical regression of penile lesions defined as
disappearance of lesions at penoscopy. Potentially prognostic factors,
i.e., HPV status, lesion type and age, were studied as well. Outcomes
were assessed in 57 men of the condom group and in 43 men of the
noncondom group. Condom use shortened the median time to regression of
flat penile lesions (7.4 months condom group vs. 13.9 months noncondom
group; HR = 2.1, 95% CI 1.2-3.7). This effect was not found for
papular lesions (HR = 0.5, 95% CI 0.1-2.8). HPV-negative men showed a
significantly shorter median time to regression of flat lesions (3.8
months) compared to men with either HPV-positive status (8.5 months;
HR = 0.4, 95% CI 0.2-0.9) or inconsistent HPV status (13.1 months; HR
= 0.2, 95% CI 0.1-0.6). Regression of flat penile lesions is
HPV-dependent and accelerated by condom use. This effect is probably
the result of blocking viral transmission between sexual partners.
Copyright 2003 Wiley-Liss, Inc.

**
Williams SS, Norris AE, Bedor MM. Sexual relationships, condom use,
and concerns about pregnancy, HIV/AIDS, and other sexually transmitted
diseases. Clin Nurse Spec. 2003 Mar;17(2):89-94.

University of Illinois at Urbana-Champaign, IL, USA.

As we move further into the 21st century, there are increasing numbers
of teenagers and young adults infected with sexually transmitted
diseases and acquired immunodeficiency syndrome. Aside from sexual
abstinence, condom use is the best way to protect oneself from
sexually transmitted diseases, including human immunodeficiency
virus/acquired immunodeficiency syndrome. Participants in this study
were predominantly female, predominantly Caucasian psychology students
who experienced sexual intercourse with an opposite sex partner in the
past year. Slightly fewer than half of these participants reported
condom use at their last episode of vaginal intercourse and type of
partner did not affect their condom use, nor did concern about human
immunodeficiency virus/acquired immunodeficiency syndrome and sexually
transmitted diseases. Findings such as these challenge advanced
practice nurses to generate innovative strategies to promote condom
use in all types of relationships. We propose that teaching about the
link between cervical cancer and lack of condom use could be one of
these new strategies.

**
Manhart LE, Koutsky LA. Do condoms prevent genital HPV infection,
external genital warts, or cervical neoplasia? A meta-analysis. Sex
Transm Dis. 2002 Nov;29(11):725-35.

Department of Medicine, University of Washington, Seattle, Washington,
USA.

BACKGROUND: Although condoms most likely prevent HIV infection,
evidence of their effectiveness against other sexually transmitted
diseases is mixed. GOAL: The goal of the study was to determine
whether condom use prevents genital human papillomavirus (HPV)
infection and HPV-related conditions. STUDY DESIGN: We conducted a
literature review and meta-analysis of the effect of condom use on the
prevention of genital warts, subclinical HPV infection, cervical
intraepithelial neoplasia (CIN), and invasive cervical cancer (ICC).
RESULTS: Among 27 estimates from 20 studies, there was no consistent
evidence that condom use reduces the risk of becoming HPV
DNA-positive. However, risk for genital warts, CIN of grade II or III
(CIN II or III), and ICC was somewhat reduced. CONCLUSIONS: Available
data are too inconsistent to provide precise estimates. However, they
suggest that while condoms may not prevent HPV infection, they may
protect against genital warts, CIN II or III, and ICC.

**
No risk from nitrosamine content in condoms.

Proksch E. Toxicological evaluation of nitrosamines in condoms. Int J
Hyg Environ Health. 2001 Nov;204(2-3):103-10.

Klinik fur Dermatologie, Venerologie und Allergologie, Universitat
Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany.
eproksch@dermatology.uni-kiel.de

Volatile N-nitrosamines have been found in rubber products including
gloves, balloons, toys, baby bottle teats, soothers, and condoms.
N-Nitrosamines are potent carcinogens, and therefore, European
legislation has limited the release of N-nitrosamines and
N-nitrosatable compounds in teats and soothers to 0.01-0.1 mg/kg
rubber, respectively. Previously, endogenous nitrosamine formation in
the vagina has been suggested as a cause of cervical cancer. It was
speculated that exogenous N-nitrosamines and N-nitrosatable compounds
from condoms may also lead to genital cancer. Therefore, we reviewed
the literature and calculated the risk for the induction of tumors by
nitrosamines from condoms. In vitro Biaudet et al. (1997) found up to
88 ng nitrosatable compounds migrating from condoms to cervical mucous
within 24 hrs. During sexual intercourse about 0.6 ng may migrate in
the female genital mucous membranes because of the short contact to
the condom, e.g. 10 min. Comparable amounts of nitrosamines may also
migrate in the penile skin. Estimating 1500 contacts to condoms during
lifetime (50 condoms/year for 30 years) this may result in the
adsorption of up to 0.9 microgram nitrosamines in total. Animal
studies in Syrian hamsters showed the induction of local and/or
systemic tumors, in particular liver tumors, after topical application
of nitrosamines to the skin or mucous membrane at a total dose of
about 1 g. This dose exceeds the dose to be expected from contact with
condoms by more than 1 million. Also, epidemiological studies do not
support a role for condoms in the induction of cancer. The incidence
of cervical cancer and liver tumors is high in developing countries,
where condoms are seldom used. In addition, humans are regularly
exposed to nitrosamines from food and tobacco smoke at a dose which is
1,000 to 10,000 fold higher than expected from condom use. In summary,
the risk for the induction of tumors from nitrosamines in condoms is
very low.
PaulKing - 24 Jun 2005 07:41 GMT
"In addition, humans are regularly
exposed to nitrosamines from food and tobacco smoke at a dose which is
1,000 to 10,000 fold higher than expected from condom use."

The latest German study found the level was FOUR TIMES HIGHER than the
highest levels ever found in food stuffs and 'cause for concern'.

So much for your outdated information.

AS FOR CONDOMS AS PROTECTION

Editor of Rubber Chemistry and Technology, Dr. C. Michael Roland of the
U.S. Naval Research Laboratory in Washington D.C., spoke about his
research on "intrinsic flaws" in latex rubber condoms and surgical gloves
(published in Rubber World, June, 1993).

Roland said that what I am about to relate is "common knowledge among good
scientists who have no political agenda."

Electron microscopy reveals the HIV virus to be about O.1 microns in size
(a micron is a millionth of a metre). It is 60 times smaller than a
syphilis bacterium, and 450 times smaller than a single human sperm.

The standard U.S. government leakage test (ASTM) will detect water leakage
through holes only as small as 10 to 12 microns (most condoms sold in
Canada are made in the U.S.A., but I'll mention the Canadian test below).

Roland says in good tests based on these standards, 33% of all condoms
tested allowed HIV-sized particles through, and that "spermicidal agents
such as nonoxonol-9 may actually ease the passage."

Roland's paper shows electron microscopy photos of natural latex. You can
see the natural holes, or intrinsic flaws. The "inherent defects in
natural rubber range between 5 and 70 microns."

And it's not as if governments don't know. A study by Dr. R.F. Carey of
the U.S. Centers for Disease Control reports that "leakage of HIV-sized
particles through latex condoms was detectable for as many as 29 of 89
condoms tested." These were brand new, pre-approved condoms. But Roland
says a closer reading of Carey's data actually yields a 78% HIV-leakage
rate, and concludes: "That the CDC would promote condoms based on [this]
study...suggests its agenda is concerned with something other than public
health and welfare." The federal government's standard tests, he adds,
"cannot detect flaws even 70 times larger than the AIDS virus."

Such tests are "blind to leakage volumes less tha one microliter - yet
this quantity of fluid from an AIDS-infected individual has been found to
contain as
many as 100,000 HIV particles."

As one U.S. surgeon memorably put it, "The HIV virus can go through a
condom like a bullet through a tennis net."

It's the same story with latex gloves. Gloves from four different
manufacturers revealed "pits as large as 15 microns wide and 30 microns
deep." More relevant to HIV transmission, "5 micron-wide channels,
penetrating the entire thickness were found in all the gloves." He said
the presence of such defects in latex "is well established."

For Canada, the story is the same. A standard Health and Welfare Canada
test of condoms manufactured between 1987 and 1990, based on stringent
tests of pressure, leakage, and volume (as in the U.S., there is no effort
to examine micron-level leakage), reported that an astonishing 40% of the
condoms tested failed at least one of the tests. Tests in 1991 showed an
"improved" 28% rate.
GMCarter - 24 Jun 2005 12:07 GMT
>"In addition, humans are regularly
>exposed to nitrosamines from food and tobacco smoke at a dose which is
>1,000 to 10,000 fold higher than expected from condom use."
>
>The latest German study found the level was FOUR TIMES HIGHER than the
>highest levels ever found in food stuffs and 'cause for concern'.

No, it didn't. And the "latest German study" is older.

Air can fill a condom and not leak out. So can water. Surface tension.
Risk reduction. SIGNIFICANT risk reduction.

Still making cheap barebackng porn, Mark?

        George M. Carter
PaulKing - 25 Jun 2005 22:59 GMT
WRONG AGAIN LITTLE MASTER CARTER

Do Condoms Protect Against Small Viruses?
The use of condoms is widely recommended to prevent sexually transmitted
diseases, including those caused by such viruses as herpes simplex,
hepatitis B, and human immunodeficiency virus (HIV).

The efficacy of condoms in these circumstances, however, is unknown. The
water-leak test used to ensure the integrity of condoms can detect holes
as small as 3 to 4 m in diameter, but sexually transmitted viruses are
much smaller, with diameters of 0.04 to 0.15 m.

A previous study demonstrated that about one third of condoms tested
allowed penetration of HIV-sized polystyrene spheres.
GMCarter - 25 Jun 2005 23:18 GMT
>WRONG AGAIN LITTLE MASTER CARTER

Nope. You provide an uncited bit of drivel that is inaccurate.

>Do Condoms Protect Against Small Viruses?

Yes. Properly used, condoms will dramatically decrease the risk of
infection.

        George M. Carter

***
Baldwin SB, Wallace DR, Papenfuss MR, Abrahamsen M, Vaught LC,
Giuliano AR. Condom use and other factors affecting penile human
papillomavirus detection in men attending a sexually transmitted
disease clinic. Sex Transm Dis. 2004 Oct;31(10):601-7.

Department of Obstetrics and Gynecology, University of Arizona College
of Medicine, Tucson, Arizona, USA. sbaldwin@mednet.ucla.edu

BACKGROUND AND OBJECTIVES: Human papillomavirus (HPV) is the primary
cause of cervical, anal, and other anogenital cancers, but risk
factors for penile HPV detection in men have not been
well-characterized. GOAL: The goal of this study was to identify
correlates of penile HPV detection in ethnically diverse men attending
a sexually transmitted disease clinic. STUDY: A cross-sectional
investigation was conducted among 393 men. Participants completed a
risk-factor questionnaire and underwent testing for penile HPV DNA.
Presence of HPV DNA was assessed using polymerase chain reaction with
PGMY primers and reverse line blot genotyping. Logistic regression
analyses were conducted to identify variables associated with
any-type, oncogenic, and nononcogenic HPV. RESULTS: Circumcision was
associated with reduced risk for oncogenic, nononcogenic, and overall
HPV. Regular condom use was associated with reduced risk for oncogenic
and overall HPV. CONCLUSION: These findings, if confirmed by other
studies, could impact public health practices and messages regarding
HPV.

**
Price MA, Miller WC, Kaydos-Daniels SC, Hoffman IF, Chilongozi D,
Martinson FE, Namakhwa D, Malanda J, Cohen M. Trichomoniasis in men
and HIV infection: data from 2 outpatient clinics at Lilongwe Central
Hospital, Malawi. J Infect Dis. 2004 Oct 15;190(8):1448-55. Epub 2004
Sep 13.

School of Medicine, Department of Epidemiology, University of North
Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7030, USA.
mscohen@med.unc.edu.

BACKGROUND: Little is known about the epidemiologic profile of
trichomoniasis in men and its relationship to human immunodeficiency
virus (HIV) infection. Among men presenting for care for symptomatic
sexually transmitted infections (STIs) in Malawi, trichomoniasis is
not considered for first-line treatment. METHODS: We conducted a
cross-sectional survey of 1187 men attending either a dermatology or
STI outpatient clinic in the capital of Malawi. Men were interviewed,
and the etiologies of the STIs were determined. RESULTS: At the STI
clinic (n = 756 men), we identified 150 men (20%) with Trichomonas
vaginalis infection, 358 men (47%) with HIV infection, and 335 men
(44%) with Neisseria gonorrhoeae infection. At the dermatology clinic
(n = 431 men), we identified 54 (13%), 118 (27%), and 2 (0.5%) men,
respectively. At both clinics, a lower education level and reporting
never having used a condom were predictive of T. vaginalis infection.
Only at the dermatology clinic was older age associated with
infection, and only at the STI clinic were marital, genital ulcer
disease, and HIV-infection status associated with T. vaginalis
infection. At the STI clinic, urethral symptoms attributable to
trichomoniasis were more severe among HIV-positive men than among
HIV-negative men. CONCLUSIONS: Given its high prevalence and the
increased risk for HIV transmission, T. vaginalis infection should be
reconsidered for inclusion in the Malawi STI-treatment regimen for
men. Copyright 2004 Infectious Diseases Society of America

**
Langenberg A. Interrupting herpes simplex virus type 2 transmission:
the role of condoms and microbicides. Herpes. 2004 Aug;11 Suppl
3:147A-154A.

Chiron Corporation, Emeryville, Novato, CA, USA. alangenberg@bmrn.com

Condoms act as mechanical barriers to genital infection. In vitro
models demonstrate that condoms are almost impermeable to viruses. A
small amount of virus may cross the condom, but the condom can still
reduce the level of virus exposure by several orders of magnitude.
However, in vivo factors, such as condom failure during intercourse,
can potentially limit their effectiveness. The weight of available
evidence suggests that consistent and correct use of the male condom
protects against herpes simplex virus (HSV) infection, as well as
other sexually transmitted infections. Female condoms should
theoretically protect against HSV infection as they cover a large
surface area of potentially infected or susceptible tissues, but
research is needed to confirm this. The lack of acceptance, or lack of
consistent use, of condoms is the biggest barrier to their
effectiveness. There is a need for effective counselling of
individuals whose sexual behaviour increases their risk of HSV
acquisition, such as young adults. Pregnant women are likely to be
receptive to counselling due to the risk of neonatal herpes. No
commercially available microbicides specifically inhibit HSV, although
many inactivate the virus. More potent and specific microbicides are
in development, but may be more expensive than those currently
available. Although the effectiveness of condom and microbicide use is
not completely proven, there is sufficient evidence to support the
promotion of their use by healthcare professionals as an important
part of safe sex counselling.
PaulKing - 26 Jun 2005 07:27 GMT
"You provide an uncited bit of drivel that is inaccurate."

Uncited? Hardly. Do you every stop lying?
Chris Noble - 29 Jun 2005 09:27 GMT
> WRONG AGAIN LITTLE MASTER CARTER
>
[quoted text clipped - 10 lines]
> A previous study demonstrated that about one third of condoms tested
> allowed penetration of HIV-sized polystyrene spheres.

You don't give a reference for this "article".

It is taken from a journal watch
http://dermatology.jwatch.org/content/vol1997/issue601/

It does not report original work but summarises another article.

The article in this case

Sex Transm Dis 1997 Jan 1; 24:161
ishttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list
_uids=9132983&query_hl=48


RESULTS: Under test conditions, 2.6% (12 of 470) of the latex condoms
allowed some virus penetration; the median level of penetration was 7 x
10(-4) ml. Lubricated condoms performed similarly to nonlubricated
ones. Polyurethane condoms yielded results higher than but not
statistically different from those for latex condoms.

CONCLUSIONS: Few condoms allowed any virus penetration. The median
amount of penetration for latex condoms when extrapolated to expected
actual use conditions was 1 x 10(-5) ml (volume of semen). Thus, even
for the few condoms that do allow virus penetration, the typical level
of exposure to semen would be several orders of magnitude lower than
for no condom at all.

Condoms effectively reduce the exposure of semen and risk of infection
by several orders of magnitude. They are not 100% effective.

Condoms are also not 100% effective in preventing the penetration of
oxygen. Try putting one over your head and seeing how long you can
breathe for. Actually, a single case would be regarded as anecdotal.
Get all of your Denialist friends to take part in this trial, that is
if you can find a significant number.


Chris Noble

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