Medical Forum / Diseases and Disorders / AIDS / June 2005
Condom cancer risk exposed
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PaulKing - 22 Jun 2005 20:25 GMT Condom cancer risk exposed
Most condoms contain a cancer-causing chemical and their manufacture should be subject to greater quality control, a German scientific research institute said.
The Chemical and Veterinary Investigation Institute in Stuttgart, Germany, said it found the carcinogen N-Nitrosamine present in 29 of 32 types of condoms it tested in simulated conditions.
"N-Nitrosamine is one of the most carcinogenic substances," the study's authors said. "There is a pressing need for manufacturers to tackle this problem." The carcinogen is thought to be present in a substance used to improve condom elasticity. When the rubber material comes in contact with human bodily fluids, it can release traces of N-Nitrosamine, the study said. Local government officials said condom users should not stop using rubber contraceptives based on results of the study because N-Nitrosamine does not present an immediate health danger.
Germany's Federal Institute for Risk Assessment said that daily condom use exposed users to N-Nitrosamine levels up to three times higher than levels naturally present in food.
-- Reuters
GMCarter - 22 Jun 2005 22:15 GMT >Condom cancer risk exposed What risk? And again, the data that exist refute this. Previously posted.
Geez, Paul-Mark-thing, can't you come up with anything new?
George M. Carter
PaulKing - 23 Jun 2005 11:00 GMT "and again, the data that exist refute this."
No such data exists and you have failed to provide any.
Once again we get Carter lies and silly insults.
What a pathetic character you are.
GMCarter - 23 Jun 2005 23:02 GMT >"and again, the data that exist refute this." > >No such data exists and you have failed to provide any. Either you never read it or you did and you're just lying. I've posted the Proksch data frequently.
I'll repeat it and add some.
George M. Carter
** Condoms can PREVENT certain cancers:
Bleeker MC, Hogewoning CJ, Voorhorst FJ, van den Brule AJ, Snijders PJ, Starink TM, Berkhof J, Meijer CJ. Condom use promotes regression of human papillomavirus-associated penile lesions in male sexual partners of women with cervical intraepithelial neoplasia. Int J Cancer. 2003 Dec 10;107(5):804-10.
Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands.
Penile HPV-associated lesions are frequently seen in male sexual partners of women with CIN. The natural course and clinical significance of these lesions are unclear. Women with CIN and their male sexual partners were randomized for condom use (condom group n = 68, noncondom group n = 68). Males were screened for the presence of penile lesions, i.e., flat lesions, papular lesions and condylomata acuminata, and of HPV in their penile swabs by PCR testing. Median follow-up time was 13.1 months (range 2.9-57.4). The outcome of our study was clinical regression of penile lesions defined as disappearance of lesions at penoscopy. Potentially prognostic factors, i.e., HPV status, lesion type and age, were studied as well. Outcomes were assessed in 57 men of the condom group and in 43 men of the noncondom group. Condom use shortened the median time to regression of flat penile lesions (7.4 months condom group vs. 13.9 months noncondom group; HR = 2.1, 95% CI 1.2-3.7). This effect was not found for papular lesions (HR = 0.5, 95% CI 0.1-2.8). HPV-negative men showed a significantly shorter median time to regression of flat lesions (3.8 months) compared to men with either HPV-positive status (8.5 months; HR = 0.4, 95% CI 0.2-0.9) or inconsistent HPV status (13.1 months; HR = 0.2, 95% CI 0.1-0.6). Regression of flat penile lesions is HPV-dependent and accelerated by condom use. This effect is probably the result of blocking viral transmission between sexual partners. Copyright 2003 Wiley-Liss, Inc.
** Williams SS, Norris AE, Bedor MM. Sexual relationships, condom use, and concerns about pregnancy, HIV/AIDS, and other sexually transmitted diseases. Clin Nurse Spec. 2003 Mar;17(2):89-94.
University of Illinois at Urbana-Champaign, IL, USA.
As we move further into the 21st century, there are increasing numbers of teenagers and young adults infected with sexually transmitted diseases and acquired immunodeficiency syndrome. Aside from sexual abstinence, condom use is the best way to protect oneself from sexually transmitted diseases, including human immunodeficiency virus/acquired immunodeficiency syndrome. Participants in this study were predominantly female, predominantly Caucasian psychology students who experienced sexual intercourse with an opposite sex partner in the past year. Slightly fewer than half of these participants reported condom use at their last episode of vaginal intercourse and type of partner did not affect their condom use, nor did concern about human immunodeficiency virus/acquired immunodeficiency syndrome and sexually transmitted diseases. Findings such as these challenge advanced practice nurses to generate innovative strategies to promote condom use in all types of relationships. We propose that teaching about the link between cervical cancer and lack of condom use could be one of these new strategies.
** Manhart LE, Koutsky LA. Do condoms prevent genital HPV infection, external genital warts, or cervical neoplasia? A meta-analysis. Sex Transm Dis. 2002 Nov;29(11):725-35.
Department of Medicine, University of Washington, Seattle, Washington, USA.
BACKGROUND: Although condoms most likely prevent HIV infection, evidence of their effectiveness against other sexually transmitted diseases is mixed. GOAL: The goal of the study was to determine whether condom use prevents genital human papillomavirus (HPV) infection and HPV-related conditions. STUDY DESIGN: We conducted a literature review and meta-analysis of the effect of condom use on the prevention of genital warts, subclinical HPV infection, cervical intraepithelial neoplasia (CIN), and invasive cervical cancer (ICC). RESULTS: Among 27 estimates from 20 studies, there was no consistent evidence that condom use reduces the risk of becoming HPV DNA-positive. However, risk for genital warts, CIN of grade II or III (CIN II or III), and ICC was somewhat reduced. CONCLUSIONS: Available data are too inconsistent to provide precise estimates. However, they suggest that while condoms may not prevent HPV infection, they may protect against genital warts, CIN II or III, and ICC.
** No risk from nitrosamine content in condoms.
Proksch E. Toxicological evaluation of nitrosamines in condoms. Int J Hyg Environ Health. 2001 Nov;204(2-3):103-10.
Klinik fur Dermatologie, Venerologie und Allergologie, Universitat Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany. eproksch@dermatology.uni-kiel.de
Volatile N-nitrosamines have been found in rubber products including gloves, balloons, toys, baby bottle teats, soothers, and condoms. N-Nitrosamines are potent carcinogens, and therefore, European legislation has limited the release of N-nitrosamines and N-nitrosatable compounds in teats and soothers to 0.01-0.1 mg/kg rubber, respectively. Previously, endogenous nitrosamine formation in the vagina has been suggested as a cause of cervical cancer. It was speculated that exogenous N-nitrosamines and N-nitrosatable compounds from condoms may also lead to genital cancer. Therefore, we reviewed the literature and calculated the risk for the induction of tumors by nitrosamines from condoms. In vitro Biaudet et al. (1997) found up to 88 ng nitrosatable compounds migrating from condoms to cervical mucous within 24 hrs. During sexual intercourse about 0.6 ng may migrate in the female genital mucous membranes because of the short contact to the condom, e.g. 10 min. Comparable amounts of nitrosamines may also migrate in the penile skin. Estimating 1500 contacts to condoms during lifetime (50 condoms/year for 30 years) this may result in the adsorption of up to 0.9 microgram nitrosamines in total. Animal studies in Syrian hamsters showed the induction of local and/or systemic tumors, in particular liver tumors, after topical application of nitrosamines to the skin or mucous membrane at a total dose of about 1 g. This dose exceeds the dose to be expected from contact with condoms by more than 1 million. Also, epidemiological studies do not support a role for condoms in the induction of cancer. The incidence of cervical cancer and liver tumors is high in developing countries, where condoms are seldom used. In addition, humans are regularly exposed to nitrosamines from food and tobacco smoke at a dose which is 1,000 to 10,000 fold higher than expected from condom use. In summary, the risk for the induction of tumors from nitrosamines in condoms is very low.
PaulKing - 24 Jun 2005 07:41 GMT "In addition, humans are regularly exposed to nitrosamines from food and tobacco smoke at a dose which is 1,000 to 10,000 fold higher than expected from condom use."
The latest German study found the level was FOUR TIMES HIGHER than the highest levels ever found in food stuffs and 'cause for concern'.
So much for your outdated information.
AS FOR CONDOMS AS PROTECTION
Editor of Rubber Chemistry and Technology, Dr. C. Michael Roland of the U.S. Naval Research Laboratory in Washington D.C., spoke about his research on "intrinsic flaws" in latex rubber condoms and surgical gloves (published in Rubber World, June, 1993).
Roland said that what I am about to relate is "common knowledge among good scientists who have no political agenda."
Electron microscopy reveals the HIV virus to be about O.1 microns in size (a micron is a millionth of a metre). It is 60 times smaller than a syphilis bacterium, and 450 times smaller than a single human sperm.
The standard U.S. government leakage test (ASTM) will detect water leakage through holes only as small as 10 to 12 microns (most condoms sold in Canada are made in the U.S.A., but I'll mention the Canadian test below).
Roland says in good tests based on these standards, 33% of all condoms tested allowed HIV-sized particles through, and that "spermicidal agents such as nonoxonol-9 may actually ease the passage."
Roland's paper shows electron microscopy photos of natural latex. You can see the natural holes, or intrinsic flaws. The "inherent defects in natural rubber range between 5 and 70 microns."
And it's not as if governments don't know. A study by Dr. R.F. Carey of the U.S. Centers for Disease Control reports that "leakage of HIV-sized particles through latex condoms was detectable for as many as 29 of 89 condoms tested." These were brand new, pre-approved condoms. But Roland says a closer reading of Carey's data actually yields a 78% HIV-leakage rate, and concludes: "That the CDC would promote condoms based on [this] study...suggests its agenda is concerned with something other than public health and welfare." The federal government's standard tests, he adds, "cannot detect flaws even 70 times larger than the AIDS virus."
Such tests are "blind to leakage volumes less tha one microliter - yet this quantity of fluid from an AIDS-infected individual has been found to contain as many as 100,000 HIV particles."
As one U.S. surgeon memorably put it, "The HIV virus can go through a condom like a bullet through a tennis net."
It's the same story with latex gloves. Gloves from four different manufacturers revealed "pits as large as 15 microns wide and 30 microns deep." More relevant to HIV transmission, "5 micron-wide channels, penetrating the entire thickness were found in all the gloves." He said the presence of such defects in latex "is well established."
For Canada, the story is the same. A standard Health and Welfare Canada test of condoms manufactured between 1987 and 1990, based on stringent tests of pressure, leakage, and volume (as in the U.S., there is no effort to examine micron-level leakage), reported that an astonishing 40% of the condoms tested failed at least one of the tests. Tests in 1991 showed an "improved" 28% rate.
GMCarter - 24 Jun 2005 12:07 GMT >"In addition, humans are regularly >exposed to nitrosamines from food and tobacco smoke at a dose which is >1,000 to 10,000 fold higher than expected from condom use." > >The latest German study found the level was FOUR TIMES HIGHER than the >highest levels ever found in food stuffs and 'cause for concern'. No, it didn't. And the "latest German study" is older.
Air can fill a condom and not leak out. So can water. Surface tension. Risk reduction. SIGNIFICANT risk reduction.
Still making cheap barebackng porn, Mark?
George M. Carter
PaulKing - 25 Jun 2005 22:59 GMT WRONG AGAIN LITTLE MASTER CARTER
Do Condoms Protect Against Small Viruses? The use of condoms is widely recommended to prevent sexually transmitted diseases, including those caused by such viruses as herpes simplex, hepatitis B, and human immunodeficiency virus (HIV).
The efficacy of condoms in these circumstances, however, is unknown. The water-leak test used to ensure the integrity of condoms can detect holes as small as 3 to 4 m in diameter, but sexually transmitted viruses are much smaller, with diameters of 0.04 to 0.15 m.
A previous study demonstrated that about one third of condoms tested allowed penetration of HIV-sized polystyrene spheres.
GMCarter - 25 Jun 2005 23:18 GMT >WRONG AGAIN LITTLE MASTER CARTER Nope. You provide an uncited bit of drivel that is inaccurate.
>Do Condoms Protect Against Small Viruses? Yes. Properly used, condoms will dramatically decrease the risk of infection.
George M. Carter
*** Baldwin SB, Wallace DR, Papenfuss MR, Abrahamsen M, Vaught LC, Giuliano AR. Condom use and other factors affecting penile human papillomavirus detection in men attending a sexually transmitted disease clinic. Sex Transm Dis. 2004 Oct;31(10):601-7.
Department of Obstetrics and Gynecology, University of Arizona College of Medicine, Tucson, Arizona, USA. sbaldwin@mednet.ucla.edu
BACKGROUND AND OBJECTIVES: Human papillomavirus (HPV) is the primary cause of cervical, anal, and other anogenital cancers, but risk factors for penile HPV detection in men have not been well-characterized. GOAL: The goal of this study was to identify correlates of penile HPV detection in ethnically diverse men attending a sexually transmitted disease clinic. STUDY: A cross-sectional investigation was conducted among 393 men. Participants completed a risk-factor questionnaire and underwent testing for penile HPV DNA. Presence of HPV DNA was assessed using polymerase chain reaction with PGMY primers and reverse line blot genotyping. Logistic regression analyses were conducted to identify variables associated with any-type, oncogenic, and nononcogenic HPV. RESULTS: Circumcision was associated with reduced risk for oncogenic, nononcogenic, and overall HPV. Regular condom use was associated with reduced risk for oncogenic and overall HPV. CONCLUSION: These findings, if confirmed by other studies, could impact public health practices and messages regarding HPV.
** Price MA, Miller WC, Kaydos-Daniels SC, Hoffman IF, Chilongozi D, Martinson FE, Namakhwa D, Malanda J, Cohen M. Trichomoniasis in men and HIV infection: data from 2 outpatient clinics at Lilongwe Central Hospital, Malawi. J Infect Dis. 2004 Oct 15;190(8):1448-55. Epub 2004 Sep 13.
School of Medicine, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7030, USA. mscohen@med.unc.edu.
BACKGROUND: Little is known about the epidemiologic profile of trichomoniasis in men and its relationship to human immunodeficiency virus (HIV) infection. Among men presenting for care for symptomatic sexually transmitted infections (STIs) in Malawi, trichomoniasis is not considered for first-line treatment. METHODS: We conducted a cross-sectional survey of 1187 men attending either a dermatology or STI outpatient clinic in the capital of Malawi. Men were interviewed, and the etiologies of the STIs were determined. RESULTS: At the STI clinic (n = 756 men), we identified 150 men (20%) with Trichomonas vaginalis infection, 358 men (47%) with HIV infection, and 335 men (44%) with Neisseria gonorrhoeae infection. At the dermatology clinic (n = 431 men), we identified 54 (13%), 118 (27%), and 2 (0.5%) men, respectively. At both clinics, a lower education level and reporting never having used a condom were predictive of T. vaginalis infection. Only at the dermatology clinic was older age associated with infection, and only at the STI clinic were marital, genital ulcer disease, and HIV-infection status associated with T. vaginalis infection. At the STI clinic, urethral symptoms attributable to trichomoniasis were more severe among HIV-positive men than among HIV-negative men. CONCLUSIONS: Given its high prevalence and the increased risk for HIV transmission, T. vaginalis infection should be reconsidered for inclusion in the Malawi STI-treatment regimen for men. Copyright 2004 Infectious Diseases Society of America
** Langenberg A. Interrupting herpes simplex virus type 2 transmission: the role of condoms and microbicides. Herpes. 2004 Aug;11 Suppl 3:147A-154A.
Chiron Corporation, Emeryville, Novato, CA, USA. alangenberg@bmrn.com
Condoms act as mechanical barriers to genital infection. In vitro models demonstrate that condoms are almost impermeable to viruses. A small amount of virus may cross the condom, but the condom can still reduce the level of virus exposure by several orders of magnitude. However, in vivo factors, such as condom failure during intercourse, can potentially limit their effectiveness. The weight of available evidence suggests that consistent and correct use of the male condom protects against herpes simplex virus (HSV) infection, as well as other sexually transmitted infections. Female condoms should theoretically protect against HSV infection as they cover a large surface area of potentially infected or susceptible tissues, but research is needed to confirm this. The lack of acceptance, or lack of consistent use, of condoms is the biggest barrier to their effectiveness. There is a need for effective counselling of individuals whose sexual behaviour increases their risk of HSV acquisition, such as young adults. Pregnant women are likely to be receptive to counselling due to the risk of neonatal herpes. No commercially available microbicides specifically inhibit HSV, although many inactivate the virus. More potent and specific microbicides are in development, but may be more expensive than those currently available. Although the effectiveness of condom and microbicide use is not completely proven, there is sufficient evidence to support the promotion of their use by healthcare professionals as an important part of safe sex counselling.
PaulKing - 26 Jun 2005 07:27 GMT "You provide an uncited bit of drivel that is inaccurate."
Uncited? Hardly. Do you every stop lying?
Chris Noble - 29 Jun 2005 09:27 GMT > WRONG AGAIN LITTLE MASTER CARTER > [quoted text clipped - 10 lines] > A previous study demonstrated that about one third of condoms tested > allowed penetration of HIV-sized polystyrene spheres. You don't give a reference for this "article".
It is taken from a journal watch http://dermatology.jwatch.org/content/vol1997/issue601/
It does not report original work but summarises another article.
The article in this case
Sex Transm Dis 1997 Jan 1; 24:161 ishttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list _uids=9132983&query_hl=48
RESULTS: Under test conditions, 2.6% (12 of 470) of the latex condoms allowed some virus penetration; the median level of penetration was 7 x 10(-4) ml. Lubricated condoms performed similarly to nonlubricated ones. Polyurethane condoms yielded results higher than but not statistically different from those for latex condoms.
CONCLUSIONS: Few condoms allowed any virus penetration. The median amount of penetration for latex condoms when extrapolated to expected actual use conditions was 1 x 10(-5) ml (volume of semen). Thus, even for the few condoms that do allow virus penetration, the typical level of exposure to semen would be several orders of magnitude lower than for no condom at all.
Condoms effectively reduce the exposure of semen and risk of infection by several orders of magnitude. They are not 100% effective.
Condoms are also not 100% effective in preventing the penetration of oxygen. Try putting one over your head and seeing how long you can breathe for. Actually, a single case would be regarded as anecdotal. Get all of your Denialist friends to take part in this trial, that is if you can find a significant number.
Chris Noble
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