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Medical Forum / Diseases and Disorders / AIDS / May 2005

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"Condom cancer risk exposed" - ABC/Reuters

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PaulKing - 18 May 2005 23:23 GMT
Condom cancer risk exposed

Most condoms contain a cancer-causing chemical and their manufacture
should be subject to greater quality control, a German scientific research
institute said.

The Chemical and Veterinary Investigation Institute in Stuttgart, Germany,
said it found the carcinogen N-Nitrosamine present in 29 of 32 types of
condoms it tested in simulated conditions.

"N-Nitrosamine is one of the most carcinogenic substances," the study's
authors said.

"There is a pressing need for manufacturers to tackle this problem."

The carcinogen is thought to be present in a substance used to improve
condom elasticity.
When the rubber material comes in contact with human bodily fluids, it can
release traces of N-Nitrosamine, the study said.

Local government officials said condom users should not stop using rubber
contraceptives based on results of the study because N-Nitrosamine does
not present an immediate health danger.

Germany's Federal Institute for Risk Assessment said that daily condom use
exposed users to N-Nitrosamine levels up to three times higher than levels
naturally present in food.

-- Reuters

http://www.abc.net.au/news/newsitems/s1118849.htm
PaulKing - 18 May 2005 23:37 GMT
...and this is just ONE of the many carcinogens in condoms.

No study has been conducted on their combined effect.

Really scary stuff.
GMCarter - 19 May 2005 10:16 GMT
>Condom cancer risk exposed

Note from the article:
"Local government officials said condom users should not stop using
rubber contraceptives based on results of the study because
N-Nitrosamine does not present an immediate health danger."

Yet another study I have REPEATEDLY posted here, not a news report
about an unnamed study, found no such risk.

        George M. Carter

**
Proksch E. Toxicological evaluation of nitrosamines in condoms. Int J
Hyg Environ Health. 2001 Nov;204(2-3):103-10.

Klinik fur Dermatologie, Venerologie und Allergologie, Universitat
Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany.

Volatile N-nitrosamines have been found in rubber products including
gloves, balloons, toys, baby bottle teats, soothers, and condoms.
N-Nitrosamines are potent carcinogens, and therefore, European
legislation has limited the release of N-nitrosamines and
N-nitrosatable compounds in teats and soothers to 0.01-0.1 mg/kg
rubber, respectively. Previously, endogenous nitrosamine formation in
the vagina has been suggested as a cause of cervical cancer. It was
speculated that exogenous N-nitrosamines and N-nitrosatable compounds
from condoms may also lead to genital cancer. Therefore, we reviewed
the literature and calculated the risk for the induction of tumors by
nitrosamines from condoms. In vitro Biaudet et al. (1997) found up to
88 ng nitrosatable compounds migrating from condoms to cervical mucous
within 24 hrs. During sexual intercourse about 0.6 ng may migrate in
the female genital mucous membranes because of the short contact to
the condom, e.g. 10 min. Comparable amounts of nitrosamines may also
migrate in the penile skin. Estimating 1500 contacts to condoms during
lifetime (50 condoms/year for 30 years) this may result in the
adsorption of up to 0.9 microgram nitrosamines in total. Animal
studies in Syrian hamsters showed the induction of local and/or
systemic tumors, in particular liver tumors, after topical application
of nitrosamines to the skin or mucous membrane at a total dose of
about 1 g. This dose exceeds the dose to be expected from contact with
condoms by more than 1 million. Also, epidemiological studies do not
support a role for condoms in the induction of cancer. The incidence
of cervical cancer and liver tumors is high in developing countries,
where condoms are seldom used. In addition, humans are regularly
exposed to nitrosamines from food and tobacco smoke at a dose which is
1,000 to 10,000 fold higher than expected from condom use. In summary,
the risk for the induction of tumors from nitrosamines in condoms is
very low.

**
Here's a study that only dimly supports the notion. Here, it shows the
per condom release rate to be lower than the standards of the German
government. Modestly more than one gets from eating--I know few people
who screw more than they eat. In fact, no one.

Altkofer W, Braune S, Ellendt K, Kettl-Gromminger M, Steiner G.
Migration of nitrosamines from rubber products--are balloons and
condoms harmful to the human health? Mol Nutr Food Res. 2005
Mar;49(3):235-8.

Chemisches und Veterinaeruntersuchungsamt Stuttgart, Fellbach,
Germany.

   Studies performed in 2001 and 2003 surveyed the release of
carcinogenic nitrosamines and nitrosatable substances from rubber toy
balloons by extraction with artificial saliva and gas
chromatography-thermal energy analysis (GC-TEA). 81% of the 16 in 2001
sampled balloons and 93% of the 14 in 2003 sampled balloons released
nitrosamines above the recommended level in Germany of 10 mug per kg
material. Furthermore, 32 rubber condom samples collected in 2004 from
the German market were surveyed for nitrosamines by determining the
amount migrating into an artificial sweat test solution. The levels
released from condoms varied from < 10 to 660 mug per kg material (i.
e., up to 1.4 mug nitrosamines per condom). In a model calculation,
not considering the differences that may exist in the resorption rate,
we have calculated that the exposure from condoms may exceed the
exposure from food 1.5-3 fold. To our knowledge so far no legal
binding legislation exists worldwide concerning nitrosamine migration
from toy balloons or condoms.
 
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