Several drugs used to treat HIV, AIDS and depression can affect sexual
function. Megestrol acetate (Megace), an appetite stimulant, can cause
loss of libido, and the anti-depressant fluoxetine (Prozac) can make it
harder for men to ejaculate. Drugs that cause neuropathy, such as ddI, d4T
and ddC, can sometimes cause numbness in the genital area that can affect
sexual function.

Several studies have found an association between combination
antiretroviral therapy, particularly protease inhibitors, and sexual
dysfunction, but no mechanism to explain this phenomenon has been
suggested yet.

Spanish researchers found that 14 out of 260 men who had started protease
inhibitor treatment reported erectile dysfunction within the first 14
months of treatment. Another study found that, even when controlling for
depression and age, men were over three times more likely to experience
impotence after starting protease inhibitors.

http://www.aidsmap.com/en/docs/562BF1EC-7808-4C85-B9A0-0E66800683C9.asp

_______

“[Chapters in this guide to HIV drugs are entitled Introduction, Appetite
loss, Body distortions (lipodystrophy), Bone death and destruction,
Cardiac concerns, Diarrhea, Fatigue, Gas and bloating, Hair loss,
Headaches, Insulin resistance and diabetes, Kidney stones, Liver toxicity,
Muscle aches and pains, Nausea and vomiting, Nightmares, daymares and
sleeping difficulties, Pancreatitis, Peripheral neuropathy, Skin problems,
Sexual difficulties, The end]”
– A Practical Guide to HIV Drug Side Effects, CATIE, 2002