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Medical Forum / Diseases and Disorders / AIDS / February 2005

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new aids found in NY

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Death - 12 Feb 2005 02:10 GMT
NYC Health Officials Find New, Virulent HIV Strain (Update7)
Feb. 11 (Bloomberg) --

New York City doctors have discovered a man with a previously unseen strain
of HIV that is resistant to three of the four types of anti-viral drugs that
combat the disease, and progresses from infection to full-blown AIDS in two
or three months, the health department said.

``We've identified this strain of HIV that is difficult or impossible to
treat and which appears to progress rapidly to AIDS,'' said New York City
Health Commissioner Thomas Frieden. ``We have not seen a case like this
before. It holds the potential for a very serious public health problem.''

The case was diagnosed in a New Yorker in his mid-40s who reported multiple
male sex partners and unprotected anal sex -- often while using the drug
crystal methamphetamine.

``It is likely there are others infected with this strain and this
individual has infected others,'' Frieden said. The case is ``extremely
concerning and a wake-up call,'' he said.

Antonio Urbina, medical director of HIV education and training at St.
Vincent's Catholic Medical Center, site of one of Manhattan's largest AIDS
clinics, said the patient's use of crystal methamphetamine shows that the
drug ``continues to play a significant role in facilitating the transmission
of HIV.'' The drug reduces peoples' inhibitions and their likelihood of
using condoms or other forms of safe sex, he said.

`Alarming'

While drug resistance is increasingly common among patients who have been
treated for HIV, cases of three-class antiretroviral-resistant HIV -- or
3-DCR HIV -- in newly diagnosed, previously untreated patients are extremely
rare, and the combination of this pattern of drug resistance and rapid
progression to AIDS may not have been seen previously, the health department
said in a news release.

The strain found in New York was ``highly unusual,'' said Ronald Valdiserri,
53, deputy director of the National Center for HIV, Sexually Transmitted
Diseases and Tuberculosis at the U.S. Centers for Disease Control and
Prevention, in an interview.

``We're talking about a single case, but clearly the fact that we are
dealing with such broad resistance of drugs and the rapid clinical
progression is quite alarming,'' Valdiserri said.

U.S. health officials intend to contact clinics across the country to set up
a surveillance system for the HIV strain, he said. City officials are
working to identify, contact and counsel the patient's sex partners, Frieden
said.

Fuzeon

Frieden said the one drug the HIV strain isn't resistant to is Enfuvirtide,
sold under the trade name Fuzeon, developed by Trimeris Inc. of Durham,
North Carolina, and Roche Holding AG of Switzerland. The problem, Frieden
and other physicians said, is that this drug is most effective when used in
a ``cocktail'' with other retrovirus drugs such as nucleoside reverse
transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors
and protease inhibitors.

Trimeris stock closed at $13.60, up 86 cents or 6.75 percent, in composite
trading on the Nasdaq, the biggest single- day percentage gain since Sept.
10, when it rose 11.49 percent, and down $4.63 from $17.93 a year ago. Roche
shares traded at 123.2 Swiss Francs, up 0.5 francs, in composite trading in
Zurich, down six Swiss Francs from a year ago.

The news ``is probably positive for Trimeris,'' said Sharon Seiler, a
biotech analyst with New York-based Punk, Ziegel & Co., which she said owns
no shares in the company, though it does act as a market maker. Fuzeon's
required twice-daily injections and the need to mix the solution for 20
minutes ``have been significant impediments to the drug's sales'' in two
years on the market, she said.

Fast Onset

The drug, which costs a patient an average $20,000, is the first in a class
called fusion inhibitors that work by preventing HIV from infecting healthy
cells.

The infected New Yorker had gone for AIDS tests frequently over the years
and tested negatively until December, when he tested positive for the virus,
Frieden said. Physicians believe he became infected in October.

``In this patient's case, onset of AIDS appears to have occurred within two
or three months and at most 20 months after HIV infection,'' Frieden said.
The patient, whose name was withheld, has symptoms usually associated ``with
someone who has very advanced disease,'' he said.

The normal time of progression from infection to full-blown AIDS in an
untreated patient is about nine years, with death following within 18
months, said Karlie Stanton, a spokeswoman for the CDC in Atlanta. For
someone treated with anti-viral drugs, the average progression to disease
from infection is 11 years, with death occurring within an average six
years, Stanton said.

Watching for Cases

Doctors at the Aaron Diamond AIDS Research Center in Manhattan diagnosed the
patient, Frieden said. David Ho, director of the center, said that while
this represents a single case, ``it is prudent to closely watch for any
additional possible cases while continuing to emphasize the importance of
reducing HIV risk behavior.''

Persons diagnosed and living with HIV/AIDS in New York City totaled 88,479
out of a total population of 7.3 million in calendar year 2003, the last
year in which statistics are available.

To contact the reporter on this story:
Henry Goldman at New York City Hall  hgoldman@bloomberg.net

To contact the editor responsible for this story:
Edward DeMarco at  edemarco1@bloomberg.net.
Last Updated: February 11, 2005 18:29 EST
Gomez Addams - 12 Feb 2005 07:21 GMT
"Death" <Death@yourdoor.net> wrote...
> NYC Health Officials Find New, Virulent HIV Strain (Update7)
> Feb. 11 (Bloomberg) --
[quoted text clipped - 8 lines]
> Health Commissioner Thomas Frieden. ``We have not seen a case like this
> before. It holds the potential for a very serious public health problem.''

Unbelievable!  Just imagine, the HIV virus randomly mutated resistance to
each of the 4 major drugs used in the cocktail treatments.  That's the
only possible explanation, because the other is heresy - that people who
KNOW they are infected BECAUSE they are taking the cocktail drugs, are
DELIBERATELY engaging in unprotected, uninformed sex.  That is just
impossible, because it is a fact that those who learn of their HIV+ status
suddenly become celibate.  Why if this politically incorrect perception
spreads, there might be calls for forced quarantine.
RamRod Sword of Baal - 12 Feb 2005 21:06 GMT
> That is just  impossible, because it is a fact that those who learn of
> their HIV+ status
> suddenly become celibate.  Why if this politically incorrect perception
> spreads, there might be calls for forced quarantine.

I have seen before where statements are made about quarantine of people with
HIV, so let us look at the logistics of it and see just how practical it
is...

Estimated number of people infected in the USA

One Million in 2003

http://www.avert.org/statsum.htm

Or 950,000

http://www.medicalnewstoday.com/medicalnews.php?newsid=17371

Now it is 2005, but let us stick with the one million for arguments sake.

OK so where are you going to quarantine 1 million people?

What state wants 1 million people with AIDS living within its borders, and
what city wants all these people living in it or near it??

Who is going to pay to keep these people?

If you quarantine them, they cannot work, so what will they do?

If people are threatened with being locked up how many will be tested?

What  sort of buildings are going to be provided for these 1 million
persons.

Who will police them, police that are infected?

How are you going to keep them quarantined, walls, razor wire, electric
fences?

The cost of keeping someone in prison in 2001 was $22,629, for people with
HIV/AIDS I would expect it to be more, the cost for a million people at
least $22,629,000,000.
Plus of course you need the money to build the facilities to hold them. At
the moment the jails in the US are overflowing so that is not an option.

http://www.motherjones.com/news/special_reports/prisons/alternatives.html

If a father is found to be HIV positive, and quarantined, who is going to
pay to keep his family, or do we toss the wife and kids in with him?
If a mother is HIV positive who is going to look after the children when she
is taken away? The State, more costs to be added to the $22,629,000,000!

Then of course you need to work out how to separate the various people you
have quarantined, after all a high bred religious white man might not like
being in a cell with a drug addict.

If a new set of facilities to hold all the HIV positive people he is some
indication of the cost, a new jail with 300 beds is going to cost 12
million, want to multiply that out for 1 million?
I think it comes up to around 40 billion.......

http://www.kltv.com/Global/story.asp?S=2925579&nav=1TjDWBYs

Just a few thought for you to think on.
Gomez Addams - 12 Feb 2005 23:27 GMT
"RamRod Sword of Baal" <RamRod Sword of Baal @truthonly.com> wrote...
> OK so where are you going to quarantine 1 million people?
>
> What state wants 1 million people with AIDS living within its borders, and
> what city wants all these people living in it or near it??

Good question, though remember that if quarantine is effective, the one
million infected will gradually die off and no new cases SHOULD occur
once they have been removed from the general population.  And I'm not
sure if it's big enough, but one of the smaller islands of Hawaii was
used as a leper colony for many years.


> Who is going to pay to keep these people?
>
> If you quarantine them, they cannot work, so what will they do?

Well, the AIDS patient I already know don't work, almost all of them
live off welfare benefits, some sort of "disability status," and
some live in public housing.  Also, I do not want to work around HIV+
people, I don't care how "harmless" you commies make the virus out to
be, I don't want to be around it.  Accidents happen and at any time
blood might be spilled, they might leave the bloody straw or needle
they used for tweek laying around, or whatever.  I do not want my
McBurger served by someone who looks like a corpse - regardless of
how "harmless" y'all claim it is in such situations, it is still
DISGUSTING and I will lose my appetite.

> If people are threatened with being locked up how many will be tested?

Remember that I had advocated FORCED testing and quarantine.  And keep
in mind that I am very libertarian, but I do not see what civil right
people have to infect others with deadly diseases.

> What  sort of buildings are going to be provided for these 1 million
> persons.
[quoted text clipped - 3 lines]
> How are you going to keep them quarantined, walls, razor wire, electric
> fences?

Cuba (the socialist workers' paradise you admire so much) keeps them behind
barbed wire, according to a documentary I saw.  The video zoomed in on the
barbed wire fence, showing it to be covered with dried blood.  Apparently
the inmates/patients deliberately cut themselves of the wire, hoping that
passers-by will poke themselves and get infected.
occupant - 13 Feb 2005 01:07 GMT
> "RamRod Sword of Baal" <RamRod Sword of Baal @truthonly.com> wrote...
> > OK so where are you going to quarantine 1 million people?
[quoted text clipped - 7 lines]
> sure if it's big enough, but one of the smaller islands of Hawaii was
> used as a leper colony for many years.

You forgot one thing.  Millions of passengers from around the world who
had sex and did drugs the
day before arriving in this country or that country can spread aids.
But nobody gets aids if they don't have
unprotected sex.  And the leper colony was a time before people
travelled like they do now and medical treatment was different than it
is today.

> > Who is going to pay to keep these people?
> >
[quoted text clipped - 3 lines]
> live off welfare benefits, some sort of "disability status," and
> some live in public housing.

Well, I guess that depends where in the world they live and what
facilities, benefits and treatments
are available to that particular individual.

Also, I do not want to work around HIV+
> people, I don't care how "harmless" you commies make the virus out to
> be, I don't want to be around it.

How would you know if somebody had AIDS?  They show no symptoms for
years.

> Accidents happen and at any time
> blood might be spilled, they might leave the bloody straw or needle
> they used for tweek laying around, or whatever.

The AIDS virus dies within minutes of hitting air; however the hepatitis
virus can be infectious for weeks
unseen by the naked eye.  

>  I do not want my
> McBurger served by someone who looks like a corpse - regardless of
> how "harmless" y'all claim it is in such situations, it is still
> DISGUSTING and I will lose my appetite.

Considering the age of most McBerger workers, how involved in loving
making activities
and drinking they are, I would worry a lot more about a host of other
diseases than
AIDS.  

> > If people are threatened with being locked up how many will be tested?
>
> Remember that I had advocated FORCED testing and quarantine.  And keep
> in mind that I am very libertarian, but I do not see what civil right
> people have to infect others with deadly diseases.

Hell, the world can't even keep track of illegal immigrants, drug
traffickers and
sex offenders and you think the world can be sure to test everybody for
aids?  Be my guest.

> > What  sort of buildings are going to be provided for these 1 million
> > persons.
[quoted text clipped - 9 lines]
> the inmates/patients deliberately cut themselves of the wire, hoping that
> passers-by will poke themselves and get infected.

Of course, you can't get AIDS from dried blood because the virus dies
within minutes of
hitting the fresh air.  Hepatitis is another story.

The other thing about Cuba is that as beautiful as it is, they is a
shorage of good medical treatment for
all it citizens as I understand it, not must fenced AIDS victims.
RamRod Sword of Baal - 13 Feb 2005 07:05 GMT
> "RamRod Sword of Baal" <RamRod Sword of Baal @truthonly.com> wrote...
>> OK so where are you going to quarantine 1 million people?
[quoted text clipped - 8 lines]
> sure if it's big enough, but one of the smaller islands of Hawaii was
> used as a leper colony for many years.

You seem big on stupid ideas, short on facts

Let me enlighten you a bit.

Molokai. (Kalaupapa) Lepers colony Hawaii

>>About 8,000 people have been exiled here since 1865, when King Kamehameha
>>V instituted an "Act to Prevent the Spread of Leprosy," that forced people
>>with leprosy or anyone suspected of having the disease to be secluded on
>>land that was set apart. The law remained in effect until 1969, when
>>admissions to Kalaupapa ended.<<

http://www.cbsnews.com/stories/2003/03/22/health/main545392.shtml

So on a leper colony that has handled 8000 people 1n around 100+ years you
would put 1 million persons, and nowhere have you said where all this
billions of dollars are coming from for your grand scheme

>> Who is going to pay to keep these people?
>>
[quoted text clipped - 10 lines]
> how "harmless" y'all claim it is in such situations, it is still
> DISGUSTING and I will lose my appetite.

You call me a commo yet you know nothing about me, and yet you wish to use
procedures that reek of the old USSR in the heyday of communism, like forced
testing, and quarantine, would you call the camps Gulags and set them up in
Alaska?

>>In the 19th century the Russian government deported around 1.2 million
>>prisoners to Siberia. Most of the revolutionary leaders in Russia spent
>>time in Siberia. This included Lenin , Leon Trotsky and Joseph Stalin.
After the Russian Revolution the labour camps in Siberia were closed down.
These were later reopened by Joseph Stalin and opponents of his regime were
sent to what became known as Glavnoye Upravleniye Lagere (Gulag).

Probably the worst of the labour camps was at Kolyma. Located in
north-eastern Siberia, temperatures drop to -90 degrees during the winter.
About 30 per cent of the prisoners in Kolyma died each year.

People sent to the Gulags included peasants who were accused of
"individualistic tendencies" and opposed the establishment of collective
farms. Large numbers of Ukrainians, Kazakhs, Uzbeks, Kirghiz, Mordovians and
Caucasians fell into this cate<<

http://www.spartacus.schoolnet.co.uk/RUSgulags.htm

====================

It seems you know little about HIV infection, there is no reason why most of
the people with HIV infection cannot work, even many who have AIDS continue
to work..

====================

>> If people are threatened with being locked up how many will be tested?

> Remember that I had advocated FORCED testing and quarantine.  And keep
> in mind that I am very libertarian, but I do not see what civil right
> people have to infect others with deadly diseases.

Libertarian?? Sorry you sound like the most rabid of the Republicans to me

Maybe you do not know what a libertarian is, let me remind you.

>> Welcome to the Official Web Site of the

The Libertarian Party is committed to America's heritage of freedom:
  individual liberty and personal responsibility
  a free-market economy of abundance and prosperity
  a foreign policy of non-intervention, peace, and free trade.
We welcome your participation and support.<<

http://www.lp.org/

Did you see that "individual liberty and personal responsibility" a far cry
from you.

From a strictly practical point of view, has anyone told you about the
period that people are infected but the tests show negative results? This
means that if you could test everyone in the US in one day, (Impossible)
then you still would have infected people running around who tested negative
while being positive.

HIV
The window period for HIV is usually 2 weeks to 3 months, but could be up to
6 months.

http://www.stdresource.com/concern/c1_d_3_a.php

Then to be effective you need to retest and retest and retest and retest,
when you are talking about 300 million people that is a rather tall order,
then of course you have people coming into the country both legally and
illegally, a further problem..

>> What  sort of buildings are going to be provided for these 1 million
>> persons.
[quoted text clipped - 10 lines]
> the inmates/patients deliberately cut themselves of the wire, hoping that
> passers-by will poke themselves and get infected.

Who said I admire Cuba, quote something I have written on Cuba.

As I said you seem to know nothing about HIV/AIDS the virus cannot live long
outside the body.
More of your pipe dreams, here again I try to educate you.

>>When it comes to the survival of HIV, we have to look at the environmental
>>conditions from the viruses perspective. Outside the human body under
[quoted text clipped - 3 lines]
>>body under normal conditions, both HIV and blood cells (red and white) die
>>rapidly.<<

http://www.thebody.com/sowadsky/answers/quest466.html

You are the one who keeps writing about your HIV+ brother aren't you, if one
believes half of what you write one must ask in madness runs in your family,
and not only with your brother..........

Let us see, hatred of gays, wanting to lock people up who have committed no
crimes, accusing me of being a communist..........
One really does wonder about your sanity.

================
======

First of all HIV/AIDS is a terrible disease, and needs to be stopped, no
question about that..

The USA way of stopping it is simply not working, Other countries of a
similar Western culture have a much better track record than the US on
stopping infections, although any infection is too many. For instance here
are the CIA factbook numbers on HIV infections listed in worse numbers
first. The figures are for HIV/AIDS - adult prevalence rate.

http://www.cia.gov/cia/publications/factbook/

USA.                   0.6% (2003 est.)
Canada                0.3% (2003 est.)
Denmark             0.2% (2003 est.)
Holland                0.2% (2001 est.)
UK                     0.1% (2001 est.)
Australia              0.1% (2003 est.)
Sweden              0.1% (2001 est.)
New Zealand     0.1% (2003 est.)
Ireland                0.1% (2001 est.)
Israel                   0.1% (2001 est.)

So seeing that the adult prevalence rate in the US is double that of Canada
and heaps worse than other countries listed, then the US should look at what
the other countries are doing to control infections.

Here in Australia, it is education, practical education, not saying do not
have sex until you are married, but telling people the truth and saying use
condoms, and also a needle exchange program for drug addicts, plus 'shooting
galleries' for addicts to shoot up safely in some major cities. It is plain
that the US idea of chastity before marriage is not an option for most
people, and is not working, the infection rates in the US bear this out.

While not all of these things are appealing to all, they seem to work here,
but of course more is needed to be done as people are still being infected.
After all we are not saying everyone likes the idea of 'shooting gallerys'
where addicts can shoot up safely, but we are talking about a bigger picture
here, the health of a nation, if not the world.

No and Australia is not perfect, we have an increase in HIV infections here,
and that is bad news.
Brian Mailman - 13 Feb 2005 02:10 GMT
> I have seen before where statements are made about quarantine of people with
> HIV, so let us look at the logistics of it and see just how practical it
> is...

<regisasadolph> Is that your Final Solution?</regisasadolph>

B/
Death - 13 Feb 2005 01:27 GMT
"Death" <Death@yourdoor.net> wrote in message

> NYC Health Officials Find New, Virulent HIV Strain (Update7)
> Feb. 11 (Bloomberg) --
[quoted text clipped - 8 lines]
> Health Commissioner Thomas Frieden. ``We have not seen a case like this
> before. It holds the potential for a very serious public health problem.''

AIDS Report Brings Alarm, Not Surprise
By RICHARD PÉREZ-PEÑA and MARC SANTORA

Published: February 13, 2005

As word spread of a rare and potentially more aggressive form of H.I.V.,
first reported publicly in New York on Friday, communities already hit hard
by the disease, professionals who combat it, and people who are infected
reacted yesterday with fear and skepticism. But few were surprised, given
that the sense of urgency about the disease has waned.

Michael Justiniano, 37, who lives in Park Slope, Brooklyn, said he watched
his father die of AIDS in 1993. "I have spoken to young kids, sometimes
here, who say, 'If I get it, it's no big deal. I can just take a pill,' " he
said. "I'm like, 'Are you stupid?' It is so disgusting. I find it really
disturbing."

City health officials announced on Friday that they had detected the rare
strain of H.I.V. in one man whose case they described as particularly
worrisome because it merged two unusual features: resistance to nearly all
anti-retroviral drugs used to treat the infection, and stunningly swift
progression from infection to full-fledged AIDS.

That combination, the officials said, could signal a new, more menacing kind
of infection, and its discovery set in motion an anxious search by city
workers to find the man's sexual partners and have them tested.

The infected man, gay and in his 40's, tested negative for H.I.V. in May
2003, then tested positive last December, health officials said.
Investigators believe he may have contracted the virus in October when he
engaged in unprotected anal sex with multiple partners while using crystal
methamphetamine. By last month, it was clear that three of the four classes
of anti-retroviral drugs used against H.I.V. were not working in this case,
and the man showed signs of AIDS, including rapid weight loss, a high level
of the virus in his bloodstream, and a depleted supply of crucial immune
system cells.

Even though the anti-retroviral "cocktail" has extended many lives, some
infected people still deteriorate and end up with AIDS, but that process
usually takes many years. Doctors say that for a patient to reach that stage
in a matter of months is extremely troubling.

AIDS experts and public health officials have long maintained that since the
development of anti-retroviral drugs in the 1990's, people have developed a
false sense that AIDS no longer poses a significant threat, leading to a
rise in unprotected sex. Clear evidence of the trend has been seen in the
growing number of cases of sexually transmitted diseases like syphilis,
chlamydia, and lymphogranuloma.

In 2003, a survey by New York City's Department of Health and Mental Hygiene
found that more than half of city residents with multiple recent sexual
partners had not been tested for H.I.V. in the previous 18 months, and 40
percent said that they had not used condoms the last time they had sex. At
the time, Dr. Thomas R. Frieden, the city health commissioner, attributed
the results to "H.I.V. precaution burnout."

Mayor Michael R. Bloomberg described the failure to take precautions against
H.I.V. in stark terms yesterday. "It's just a sin in our society, where we
know how it's transmitted from one person to another," he said, "and we
should be able to get people to conduct themselves such that they don't
catch it themselves, and certainly that they don't infect anybody else."

Unsafe sex practices combined with growing resistance to medications among
people with H.I.V., has had officials warning for years about a possible
resurgence of AIDS, a fear voiced yesterday by many people across the
country as they struggled to make sense of the news out of New York.

Oliver Palan, 19, a gay student at Baruch College, said that he had slept
with 10 men recently, and that none of them had wanted to use a condom. "So
many people are like, 'It is so much more fun without the condom,' so they
prefer to take the risk," he said, noting that he insists on using condoms.
Often, he said, partners will try to dissuade him by saying, "I trust you,
you should trust me."

Edsel Gonzalez, 30, a business owner in South Beach, the Miami Beach
neighborhood filled with nightclubs and restaurants that is popular among
gays, said he was "absolutely worried about this."

"It seems like we're moving backwards in the fight against AIDS," Mr.
Gonzalez said.
hvatum@softhome.net - 16 Feb 2005 21:25 GMT
> NYC Health Officials Find New, Virulent HIV Strain (Update7)
> Feb. 11 (Bloomberg) --
[quoted text clipped - 110 lines]
> Edward DeMarco at  edemarco1@bloomberg.net.
> Last Updated: February 11, 2005 18:29 EST

This could be a blessing in disguise. If this type of HIV becomes
prevelant then the people infected with it will die more quickly and
infect fewer people.
Death - 17 Feb 2005 01:07 GMT
<hvatum@softhome.net> wrote in message

> This could be a blessing in disguise. If this type of HIV becomes
> prevelant then the people infected with it will die more quickly and
> infect fewer people.

 February 16, 2005

Club Drugs and HIV: Possible New Strain Offers Wake-up Call
Drug use is blamed by some for contributing to the spread of HIV and AIDS.

Last Friday, the New York City Department of Health and Mental Hygiene
announced that a local man had been diagnosed with a highly resistant strain
of HIV. While people with HIV sometimes develop drug resistance over time,
this man, who had not previously been treated for HIV, has not responded to
three of the four classes of HIV drugs. He also appears to have developed
AIDS unusually quickly after becoming infected with HIV. It's possible that
there are genetic reasons for his drug resistance and for the rapid
progression from HIV to AIDS, and those issues are still being studied.

Besides his genetic makeup, another possible reason for the man's
fast-moving infection is his drug use. The unidentified man reported having
sex with multiple partners while under the influence of the club drug
methamphetamine, also known as crystal meth. It's theorized that
amphetamines may suppress the immune system, allowing the virus to replicate
more quickly in the body. Methamphetamine also contributes to unsafe sex
practices that make the spread of HIV more likely. This highly addictive
drug releases people from their inhibitions, leading otherwise sexually
responsible men, women and teenagers to engage in risky sexual behavior.

At a press conference, New York City Health Commissioner Thomas R. Frieden,
MD, MPH, said, "This case.is a wake-up call to men who have sex with men,
particularly those who may use crystal methamphetamine."

Below, Perry Halkitis, PhD, a chair of the department of applied psychology
at New York University, discusses the relationship between club drugs such
as methamphetamine and HIV infection.

What is the state of the HIV epidemic today?

We've seen a worsening of the HIV epidemic in the last several years.
Infection rates were stable during the 1990s, but in the last few years
there's been a spike in new HIV transmissions across the population,
especially among gay and bisexual men. In this population, there was a 14
percent increase in new HIV infections between 1999 and 2001.

What has lead to this increase?

First of all, there's a fatigue around HIV in the gay population and in the
general population. People feel that the HIV epidemic is over, and they're
more complacent about safer sex practices. They think there is a cure and,
as a result, people are not being as safe or as responsible in their sexual
behavior. Number two, prevention efforts haven't evolved as people have
become sophisticated about HIV. So "use a condom every time" campaigns,
which worked fine in the early 1980s and the mid-1980s, are no longer
effective.

We're also seeing a complex interaction between sexual risk-taking and drug
use in the gay population and also in the straight population. We're seeing
this in particular with a subset of drugs known as "club drugs" because of
their association with dance clubs and bars.

Are people still going to clubs to do these drugs?

Twenty years ago, these substances were used a lot in dance club situations.
Our research shows very clearly that people do them at home, they do them
with their friends, they do them in the park-they do them wherever they need
to do them. Some people have suggested that maybe a better label for them
would be "party drugs" because these are the drugs that people do to have
wild and inhibited sex, to go dancing, or to do both of those things in
combination.

Which drugs are contributing to increase HIV risk?

We're talking about methamphetamine, also known colloquially as "crystal."
We're talking about MDMA, which is known commonly as "ecstasy." We're
talking about ketamine, Rohypnol and we're still talking about cocaine, to
some extent. Most importantly, we need to think about not just each of these
drugs in isolation, but these drugs being used in combination with each
other, and in combination with alcohol and prescription drugs such as
Viagra.

Which drugs are the most worrisome and why?

Perhaps the most worrisome is methamphetamine. This is a psychostimulant and
a form of speed. Crystal is a hypersexual drug. It's a hugely disinhibiting
drug. We know, and it's been clearly documented, that people who are using
this substance have sex without rational thinking, they have multiple
partnerings, they just let go. They feel like they're on top of the world,
so nothing is a problem and any logical thinking around safer sex practices
gets wiped away. Methamphetamine is also a problem because it's a highly
addictive drug from a psychological perspective, so people have a very
difficult time coming off of it because the cravings are so intense.

Does the way methamphetamine is administered affect HIV risk?

Absolutely. When a person first starts using it, methamphetamine is usually
snorted. Eventually chronic users begin to smoke it because it is a more
effective way of ingesting the drug; it gives a better and a longer and a
faster high. Eventually, people who are dependent on the substance become
injectors of methamphetamine. They inject it in their veins or muscles
because it creates a much quicker and more intense high. So transmission
through injection and the sharing of needles and the sharing of works
creates another route of HIV transmission that is linked to methamphetamine
use.

Do we know how much club drug use is affecting HIV risk?

We know-anecdotally in New York City and from documentation on the West
Coast-that when we look at gay men who have become HIV-positive, more often
than not, in the last several years, these men report having used
methamphetamine with sex. So while we're not able to put an exact number on
it, you can bet that a large percentage of new seroconversions are among
people who are drug users.

Does methamphetamine make oral sex riskier?

We know that the mouth produces saliva, which has protective factors that
assist in the prevention of HIV. When people are high on methamphetamine,
they have extremely dry mouths. Suppose an HIV-negative person is using
methamphetamine and is having sex with an HIV-positive person. That is more
dangerous than having sex with a person who is not high on methamphetamine.

What role does depression play in drug use?

We should never deny the fact that drugs make people feel good; that's why
they do them, right? What we know, also, is that people often use drugs in
our society to mask bad feelings. So people who are experiencing depression
or loneliness or low levels of self-esteem, which can be addressed with
therapy and with medications, are self-medicating by using these substances.
The unfortunate cycle that develops is that people who are depressed, for
example, go on crystal, use crystal, feel better while they're high and then
crash and feel even worse than when they started. When we address HIV in the
United States, I think it's incredibly important that we think about the
link that exists between drug abuse, mental health and HIV. Addressing one
of those issues in isolation doesn't seem to be sophisticated any more. We
need to address all those three things together.

How does drug use affect people on HIV therapy?

What we know, from our work, is that adherence-taking your medications the
way you're supposed to take them-is a problem across the board. If we
believe the literature, people are supposed to be adherent 95 percent of the
time. It's very hard for people to be adherent 95 percent of the time when
they're high. When they're feeling good, the last thing they want to do is
actually stop to remember to take their medications. Number two, we know
that methamphetamine is an immunosuppressant. Methamphetamine that is sold
on the street is not pure methamphetamine. It's been cut with talc, heroin
and variety of other substances that have an effect on people's immune
systems. Number three, and probably most alarming of all, is that some
recent studies indicate that even if an individual is highly adherent to his
or her medications, if they are using methamphetamine, replication of the
virus in the brain is accelerated.

What is your advice to people who use methamphetamine?

To people who haven't started and who hear wonderful tales about this drug,
don't start using it. This is not a wonderful drug. The price that you will
pay in the long run is not worth it. To people who have started, I say look
for help. Because what do we know about methamphetamine and its effects on
people's lives? People become physically ill and they become socially ill.
They lose their friends, they lose their family and they lose their jobs.
Methamphetamine has often been referred to as the "Grim Reaper" because of
horrible and devastating effects it has on people's lives.

How can people reduce their risk of HIV?

Clearly, one of the strategies is abstinence from both sex and intravenous
drug use. For young adults and for adolescents, becoming totally informed
and educated about HIV and its transmission is going to be a very important
strategy, as well as considering delaying the onset of sex until an
individual is at a point where he or she can make the right choices around
sex. The consistent use of condoms, of course, is important with anonymous
or casual partners. Even in the context of some relationships that are not
monogamous, the use of condoms is actually a really good idea. Finally, the
mixing of sex and drugs is not a good idea. A glass of wine is very
different from two lines of methamphetamine. The combination of drugs and
sex is where a lot of the risk is happening now and where a lot of the
transmissions are actually occurring.

It's extremely important for individuals in our country to remain informed.
The disease is constantly changing. There are new medications that are
coming out that are effective. But people are not necessarily living their
whole lives with HIV; people are still dying. So remaining informed about
HIV and remaining informed about strategies for safer sex is important.
Death - 17 Feb 2005 01:23 GMT
<hvatum@softhome.net> wrote in message
> This could be a blessing in disguise. If this type of HIV becomes
> prevelant then the people infected with it will die more quickly and
> infect fewer people.

By Cheryl Clark
UNION-TRIBUNE STAFF WRITER
February 15, 2005

LENNY IGNELZI / Associated Press
San Diego County public health officer Dr. Nancy Bowen yesterday urged
people who think they might be infected with HIV to get tested.

An unidentified San Diego resident may be infected with the same rare,
aggressive and highly drug-resistant strain of HIV found last week in a New
York City man who has rapidly become ill with AIDS, health officials said
yesterday.

"(The local person's) HIV has a similar molecular makeup as the patient in
New York City," said Dr. Nancy Bowen, the San Diego County public health
officer who held a press conference about the finding yesterday afternoon in
San Diego.

It's important to notify the public about a new and possibly supervigorous
strain of HIV so people can take extra precautions, Bowen said. But "I don't
think it will do anybody any good to get panicked about this," she said,
emphasizing that many details are still being sorted out.

Several AIDS specialists said it was odd to see public-health officials
sound such widespread alarm after only one person became sick. They
questioned whether the virus is truly a lethal variety, or whether the New
York patient's immune system, extensive use of methamphetamines and genetic
makeup might be contributing factors to his rapidly deteriorating condition.

But public health agencies and the federal Centers for Disease Control and
Prevention said the announcement was necessary because they haven't seen an
HIV strain that becomes drug-resistant and progresses to AIDS so quickly, as
in the case of the New York man.

Bowen urged people who think they might be infected with HIV to get tested.
If infection is confirmed, the individuals should visit a doctor and request
a second blood test to determine what genetic strain of the virus they might
have.

The AIDS virus mutates regularly, changing its molecular structure over
time, so blood testing is normally done to make sure each patient's genetic
strain is vulnerable to anti-viral drugs being prescribed. If the strain
isn't vulnerable, doctors must find other medications.

Getting tested
For information on HIV testing sites, call (619) 296-2120 or contact your
primary care physician.

Bowen said the San Diego resident tested positive for the rare HIV strain
last fall - after the patient's health provider sent a sample of his or her
blood to ViroLogic, an HIV typing reference laboratory in Northern
California.

There was no alarm until the New York City man recently became ill and was
found to have a molecular strain resistant to virtually all anti-viral
drugs. His case prompted public health officials nationwide to check with
the reference lab for a similar strain among other HIV patients.

The reference lab's database then linked the New York strain to that of the
San Diego person and an unidentified New York City resident.

Researchers don't know yet whether the New York and San Diego strains are an
exact match, Bowen said. They also haven't determined if the three
individuals know one another. It will take at least a week to decide if the
HIV strains are identical, said Dr. David Ho, director of the Aaron Diamond
AIDS Research Center in Manhattan.

Federal and California health officials are trying to locate the San Diego
resident through the reference laboratory, find his or her doctor and
ultimately get in touch with the infected person. They want to see if this
individual is ill, to conduct further testing and to notify sexual partners
who may be at risk of contracting HIV.

If the person was tested under anonymous conditions, in which a name is not
given, it could be impossible to locate his or her whereabouts. The patient
also may have moved away from San Diego or died.

Health officials said the New York patient reportedly had unsafe anal sex
with hundreds of partners while taking crystal methamphetamine. The drug's
stimulating effect and erasure of inhibitions contribute to sex marathons
that have increased the spread of HIV, they explained.

Medical investigators believe that the New York patient found some of his
partners on an Internet Web site. They are working with men who used the
site to reach as many people as possible who might have been infected or are
worried about the risk.

Yesterday, Bowen reissued precautions for drug users, urging them to not
share needles or syringes. She also urged sexually active individuals to
abstain from intercourse or to commit to a long-term, mutually monogamous
relationship with a partner who has tested HIV-negative.

Correct and consistent use of a condom can reduce the risk of spreading
sexually transmitted diseases, she added.

Bowen said she hopes the finding will prompt "people who are not sure of
their (HIV) status but who are at risk to decide that they want to find out.
That's one of our main messages."

In the past three or four years, about 400 San Diego County residents each
year have been diagnosed with AIDS. In January, four new patients were
diagnosed, bringing the total number of county residents diagnosed with AIDS
since 1981 to 12,237. Of those, 54 percent have died.

The New York Times News Service contributed to this report.

Cheryl Clark: (619) 542-4573; cheryl.clark@uniontrib.com
Gomez Addams - 17 Feb 2005 18:24 GMT
<hvatum@softhome.net> wrote...
> This could be a blessing in disguise. If this type of HIV becomes
> prevelant then the people infected with it will die more quickly and
> infect fewer people.

Sadly true.  Whoever gave the guy that new strain of HIV, it is
because he had been on the cocktail drugs for probably at least
5 years.  Had he received no treatment, he would likely have
died 3-4 years ago.  That literally translates as 2x or 3x the
number of victims; also remember that the cocktail drugs create
the appearance of good health, so those taking the drugs have
the illusion of being a healthy sex partner - compare this to
the untreated HIV patient who looks very sick within a few
months of the initial appearance of symptoms, his sickly
appearance means less opportunity for finding willing sex
partners.

I know some of you find this unpleasant and want to ignore it,
but it IS what's happening.  You don't want to stop AIDS, you
just want to wear your little goodguy badges and pretend you
care about AIDS while thwarting all attempts to control the
spread of the disease as some sort of unreasonable fascism.
Let me ask y'all, is this guy with the new superstrain under
ANY sort of quarantine?  If he is free, he is certainly out
there spreading it, and the fact that the health authorties
are keeping identity a secret means the public can't protect
themselves from him.  Because you don't want to violate his
precious "civil rights," you ensure that within several years
almost EVERY new HIV infection will be the new superstrain
and therefore untreatable.

-------------------------------------------------------
"Arguing on the Internet is like running in the Special
Olympics.  Even if you win, you're still retarded."
-- Anonymous
-------------------------------------------------------
Brian Mailman - 17 Feb 2005 19:44 GMT
> I know some of you find this unpleasant and want to ignore it,
> but it IS what's happening.  You don't want to stop AIDS, you
> just want to wear your little goodguy badges and pretend you
> care about AIDS while thwarting all attempts to control the
> spread of the disease as some sort of unreasonable fascism.

you've said you're mentally unstable and need to take psychoactive
medications to remain as stable as you are (and to your credit you're a
lot better than you were a couple years ago).

i think that's definitely antisocial, and you should be euthanized.

my point is, it's a bad knife that doesn't cut both ways.

b/
GMCarter - 18 Feb 2005 02:50 GMT
snip>
>you've said you're mentally unstable and need to take psychoactive
>medications to remain as stable as you are (and to your credit you're a
[quoted text clipped - 3 lines]
>
>my point is, it's a bad knife that doesn't cut both ways.

Not to mention which there are numerous false or unproven premises at
work. It is not established that this person's rapid progression was
due to the strain of HIV he was infected with. Indeed, other data
suggest that such infections with drug resistant viruses, which have
been previously documented, do not necessarily result in rapid
progression.

Rapid progression, further, has always been a part of HIV disease for
some. Rates vary.

The bigger issue, from a public policy perspective, is how can we
manage to create programs and situations that are vigorous,
comprehensive and well-funded that will help people make better
choices or for when they decide to get off drugs like meth. Locking
people up or hoping they die won't change those behavior patterns
which a large percentage of the population engage in, sometimes for
long periods but often for only "phases" in life.

Your point, of course, is well taken. Why not kill the obese? People
who have had more than one heart attack? People who drink alcohol or
smoke cigarettes?

Nah, these boys are just looking to justify their silly bigotry.

        George M. Carter
 
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