“Pancreatitis is also a well-described complication of Videx and Zerit.”
– FDA Talk Paper, Jan 5, 2001
ddI (Videx)
Peripheral neropathy 16-34%
Pancreatitis 7-13%
Diarrhea 16-34%
Abacavir (Ziagen)
Nausea 47%
Diarrhea 12%
Decreased appetite 11%
Insomnia 7%
Hypersensitivity reaction 3-5%
Side Effects Reported Incidence Rates*
NUCLEOTIDE ANALOG
Adefovir (Preveon)
Renal (kidney) toxicities 17-32%
NNRTIs (NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS)
Nevirapine (Viramune)
Rash 24-37%
Delavirdine (Rescriptor)
Rash 18%
Neutropenia 3-7%
Elevated amylase levels 1-7%
Efavirenz (Sustiva)
Central nervous system problems (headache, insomnia, dizziness, malaise,
anxiety 25-40%
Rash 12%
Nausea 10-20%
At the Owen Clinic of the University of California, San Diego, a study of
nearly 5,000 patients who sought care for HIV showed a drop in the death
rate starting in 1995, but then an upswing among those who came to the
clinic after 1998. (5 )
A survey of almost 3,000 people enrolled in five US antiretroviral trials
between December 1996 and December 2001 plotted a dogged doubling of the
death rate every 12 months, from 3.9 percent after one year of follow-up,
to 7.9 percent after two, and to 13.1 percent after three. (6)
(5). Mathews W, Barber E. Rising mortality rates among recent entrants to
care for HIV infection. 10th Conference on Retroviruses and Opportunistic
Infections. February 10-14, 2003. Boston. Abstract 911.
(6). Reisler RB, Han C, Burman WJ, et al. Grade 4 events are as important
as AIDS events in the era of HAART. JAIDS 2003;34:379-386.
PaulKing - 08 Dec 2004 02:42 GMT
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