Side Effects Reported    Incidence Rates*
PROTEASE INHIBITORS

Saquinavir (Invirase or Fortovase)
Diarrhea    15-20%
Vomiting    3-5%
Nausea    10-15%
Acid reflux    9%
Headaches    5-9%
Fatigue    5-9%
Elevated liver enzymes    2-6%
Ritonavir (Norvir)
Weakness    9-28%
Abdominal pain    4-7%
Decreased appetite    6-8%
Nausea    23-47%
Diarrhea    18-22%
Vomiting    15-22%
Paresthesia (mouth tingling or numbness)    5-6%
Altered taste sensations    5-16%
Elevated liver enzymes    3-15%
Elevated creatinine (measure of kidney function)    7-9%
Indinavir (Crixivan)
Kidney stone or sludge/flank pain    4-37%
Elevated liver enzymes    10-12%
Abdominal pain    9%
Nausea    2-7%
Nelfinavir (Viracept)
Diarrhea    20-32%
Nausea    2-7%
Amprenavir (Agenerase)
Diarrhea    51%
Nausea    37%
Vomiting    23%
Headache    24%
Rash    28%
Paresthesia    25%
Fatigue    23%
Side Effects Reported    Incidence Rates*
NUCLEOSIDE ANALOGS
AZT (Retrovir)**
Anemia    1-29%
Granulocytopenia (shortage of a type of white blood cell)    2-37%
Abdominal pain    9%
Decreased appetite    20%
Constipation    6%
Dizziness    6%
Headache    18%
Muscle Pain    62%
Nausea    51%
Vomiting    17%
3TC (Epivir)
Diarrhea    18%
Nausea    3%
Dizziness    10%
Decreased appetite    10%
Depression    9%
Insomnia    11%
Nasal problems    20%
Headache    35%
d4T (Zerit)
Peripheral neuropathy    13-24%
Pancreatitis    7-13%
Abdominal pain    34%
Nausea and vomiting    38%
Diarrhea    50%
Headache    54%
Rash    40%
Insomnia    29%
Decreased appetite    19%
Elevated liver enzymes    11-13%
Neutropenia (shortage of a type of white blood cell)    5%
Elevated amylase levels (indicator of possible pancreatitis    14%
ddC (Hivid)
Peripheral neuropathy    22-35%
ddI (Videx)
Peripheral neropathy    16-34%
Pancreatitis    7-13%
Diarrhea    16-34%
Abacavir (Ziagen)
Nausea    47%
Diarrhea    12%
Decreased appetite    11%
Insomnia    7%
Hypersensitivity reaction    3-5%
Side Effects Reported    Incidence Rates*
NUCLEOTIDE ANALOG
Adefovir (Preveon)
Renal (kidney) toxicities    17-32%
NNRTIs (NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS)
Nevirapine (Viramune)
Rash    24-37%
Delavirdine (Rescriptor)
Rash    18%
Neutropenia    3-7%
Elevated amylase levels    1-7%
Efavirenz (Sustiva)
Central nervous system problems (headache, insomnia, dizziness, malaise,
anxiety    25-40%
Rash    12%
Nausea    10-20%

* Only side effects reported by at least 5 percent of the drug's users are
included.
** Some percentages listed here date from AZT's earliest use, with a much
higher dosage than is now recommended
POZ May 1999