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Medical Forum / Diseases and Disorders / AIDS / October 2004

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Only 38% of the HLP [Healthy long-term positives] used HAART

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PaulKing - 02 Oct 2004 23:51 GMT
“…588 men; 42 were 10-15 year non-progressors. Only 38% of the HLP [Healthy
long-term positives] had ever used zidovudine [AZT] or other nucleoside
analogues, compared with 94% of the progressors [those who developed
AIDS].”

AIDS, 8:1123 (1994)
– Buchbinder, Susan, et al, Aids Researchers
GMCarter - 03 Oct 2004 11:29 GMT
Finally--you're managing to get cites in. Sorta.

Anyway, might as well post the full abstract below. Otherwise, who
knows what you're trying to say with a snippet. Of course, people that
don't progress don't need ARV. But 38% did use AZT but didn't develop
AIDS. Good point! Duesberg and Lauritsen are full of sh.t.

And notice the last sentence. Great citation. Thanks, Paul.

        George M. Carter

>“…588 men; 42 were 10-15 year non-progressors. Only 38% of the HLP [Healthy
>long-term positives] had ever used zidovudine [AZT] or other nucleoside
[quoted text clipped - 3 lines]
>AIDS, 8:1123 (1994)
>– Buchbinder, Susan, et al, Aids Researchers

**
AIDS. 1994 Aug;8(8):1123-8.  Related Articles, Links  

Comment in:
AIDS. 1994 Aug;8(8):1179-82.

Long-term HIV-1 infection without immunologic progression.

Buchbinder SP, Katz MH, Hessol NA, O'Malley PM, Holmberg SD.

AIDS Office, Department of Public Health, San Francisco, California
94102.

OBJECTIVE: To identify and describe a subgroup of men infected with
HIV for 10-15 years without immunologic progression, and to evaluate
the effect of sexually transmitted diseases (STD) and recreational
drug use on delayed HIV disease progression. DESIGN: Inception cohort
study. SETTING: Municipal STD clinic. PARTICIPANTS: A total of 588 men
with well documented dates of HIV seroconversion and 197
HIV-seronegative controls. MAIN OUTCOME MEASURES: AIDS, CD4+ count,
rate of CD4+ cell loss, CD8+ count, beta 2-microglobulin, complete
blood count, p24 antigen and HIV-related symptoms. RESULTS: Of 588
men, 69% had developed AIDS by 14 years after HIV seroconversion (95%
confidence interval, 64-73%). Of 539 men with HIV seroconversion dates
prior to 1983, 42 men (8%) were healthy long-term HIV-positives (HLP),
HIV-infected > or = 10 years without AIDS and with CD4+ counts > 500 x
10(6)/l. When compared with progressors (men with HIV seroconversion
prior to 1983 but with AIDS or CD4+ counts < 200 x 10(6)/l), HLP had a
significantly slower rate of CD4+ decline (6 versus 85 x 10(6)/l
cells/year), and less abnormal immunologic, hematologic and clinical
parameters. However, when compared with HIV-uninfected controls, HLP
demonstrated lower CD4+ counts and mild hematologic abnormalities.
There were no consistent differences between HLP and progressors in
prior exposure to recreational drugs or STD. CONCLUSION: There are
individuals with long-term HIV infection who appear clinically and
immunologically healthy 10-15 years after HIV seroconversion, with
stable CD4+ counts. Lack of exposure to STD or recreational drugs does
not appear to explain the delayed course of disease progression in
HLP.
 
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